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Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
Introduction: The Epidermal Growth Factor Receptor (EGFR) is a transmembrane cytoplasmic protein; studies indicate that it contributes to the development and progression of potentially malignant lesions to oral squamous cell carcinoma (OSCC). In the present study we determine and characterize the ...
suggesting lower eGFR for subjects with higher RSF (r = 0.24, p < 0.0001). In conclusion, our data suggest that in the presence of NAFLD elevated fetuin-A levels may impair renal function by RSF-induced
ANA induced a decrease of EGFR levels on LNCaP, DU145, and PC3 prostatic cancer cells by acting through cannabinoid CB1 receptor subtype and this leaded to an inhibition of the EGF-stimulated growth of these cells. Moreover, the G1 arrest of metastatic DU145 and PC3 growth was accompanied ...
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mutatio
It is therefore advisable that, before to taking position on which equation should be used for estimating glomerular filtration rate (eGFR) (e.g., Chronic Kidney Disease Epidemiology Consortium 2009 vs. 2021 version), the international professional bodies more strongly support the choice of selective...
“ for bad health status. The 5-digit numbers for the five dimensions are combined and describe the patient’s health state. The Euro-Qol 5D and EQoL-VAS was formerly validated in several different settings and clinical conditions [27,28,29,30]. Estimated glomerular filtration rate (eGFR) ...
EGFR antibody cetuximab ex vivo and in vivo, showing substantial consistency in all the data levels examined. Further, we embarked on a proof-of-principle discovery effort to identify and prioritize druggable co-extinction targets, and found that inhibition of top candidates increased the depth of ...
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of