Colorectal DiseaseYang Y, Yang JJ, Tao H and Jin WS. YKL-40 and EGFR is a good biomarker for predicting nodal metastasis in anal carcinoma. Colorectal Dis 2014; 16: 69.Yang Y, Yang JJ, Tao H, Jin WS: YKL-40 and EGFR is a good biomarker for predicting nodal metastasis in anal ...
It turns out thatAsian ancestry is a major risk factor for never smoker lung cancer because of the higher likelihood of having a mutation to the epidermal growth factor receptor (EGFR) protein. The type of lung cancer that nonsmokers tend to get, called adenocarcinoma has stayed high while ot...
Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
Oropharyngeal cancer, irrespective of HPV status, is often treated with induction chemotherapy, intensified hyperfractionated radiotherapy, and the epidermal growth factor (EGF) receptor (EGFR) antibody cetuximab at advanced stages (Pignon et al, 2009; Bonner et al, 2010). However, it is largely ...
Of note, receptor tyrosine kinase (RTK) signaling, including signaling via EGFR, was also upregulated in response to UHRF1 loss. We next inferred activity of known cancer-related pathways from gene expression data using PROGENy38. In both cell lines, UHRF1 knock-down lead to an increase in...
Spigel: The big stories for me would be the adjuvant approval of atezolizumab [Tecentriq] in early-stage disease, the accelerated approval of sotorasib in KRAS G12C–mutant disease, and the accelerated approval of 2 [EGFR] exon 20 insertion therapeutics: amivantamab and mobocertinib. It’...
(A) AURKA phosphorylates RPS6KB1 is mutant K-Ras expressing cells. AURKA colocalizes and directly phosphorylates RPS6KB1 at T389 in K-Ras mutant gastrointestinal cancer cells leading to increased proliferation and survival. (B) AURKA activates EGFR signaling via SDCBP. AURKA stabilizes SDCBP by...
HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with egfr mutational status. Clin Cancer Res Off J Am Assoc Cancer Res. 2017;23(3):825–32. Article CAS Google Scholar Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y,...
In breast cancer theCXCR4mRNA promotes metastasis not only through its protein, the CXCR4 chemokine receptor, but also through theCXCR43′UTR that sponges the tumor-suppressive miR-146a, thus leading to the upregulation of TRAF6 and EGFR, two oncoproteins that activate the NF-κB pathway.148 ...
Curr Cancer Drug Targets 3: 163 – 175 Kallio JP, Hirvikoski P, Helin H, Kellokumpu-Lehtinen P, Luukkaala T, Tammela TL, Martikainen PM (2003) Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma. Br J Cancer 89: 1266 – 1269 Kallio JP, ...