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Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
Introduction: The Epidermal Growth Factor Receptor (EGFR) is a transmembrane cytoplasmic protein; studies indicate that it contributes to the development and progression of potentially malignant lesions to oral squamous cell carcinoma (OSCC). In the present study we determine and characterize the ...
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mutatio
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of
(A) AURKA phosphorylates RPS6KB1 is mutant K-Ras expressing cells. AURKA colocalizes and directly phosphorylates RPS6KB1 at T389 in K-Ras mutant gastrointestinal cancer cells leading to increased proliferation and survival. (B) AURKA activates EGFR signaling via SDCBP. AURKA stabilizes SDCBP by...
It is therefore advisable that, before to taking position on which equation should be used for estimating glomerular filtration rate (eGFR) (e.g., Chronic Kidney Disease Epidemiology Consortium 2009 vs. 2021 version), the international professional bodies more strongly support the choice of selective...
In addition, the mean duration of mechanical ventilation time (day) (P = 0.01), prolonged ICU stay (P < 0.001), and eGFR (P < 0.05) were significantly higher in the patients with VDD compared to vitamin D insufficiency and the normal group (Table 1). All-cause 28-day ...
growth factor receptor (EGFR)/PI3K/Akt signaling pathway. This stimulation leads to the feedback increase in Sodium-glucose Co-transporters (SGLT) 1 and modulates glycolysis, thereby promoting tamoxifen resistance and accelerating both in vitro and in vivo tumor growth46....
Immunomodulatory drugs (IMiDs) have become an integral part of therapy for both newly diagnosed and relapsed/refractory multiple myeloma (RRMM). IMiDs bind to cereblon, leading to the degradation of proteins involved in B-cell survival and proliferation. Thalidomide, a first-generation IMiD, has lit...