The aim of this study was to evaluate the impact of smoking on the treatment outcome of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-T... Y Ki,Cha,H Yun,... - 《Journal of Thoracic Disease》 被引量: 2发表: 2016年 An individual patient-level meta-analysis of non–...
2, comorbidities, IL-6 serum level over 75 pg/mL and PaO2/FiO2 below 250 were associated with an increased risk of death (nearly significant). AKI also correlated with a significant increase in the risk of death (OR 3.1, CI 1.6–6 p < 0.001), while deltaGFR over 10 mL/min...
Among the baseline characteristics were trial arm, level of education, race, gender, age, and Addiction Severity Index (ASI) composite scores. The baseline stimulant UA was the mediator, and the total count of stimulant-negative urine analyses during the treatment period represented the primary ...
We divided the HCC patients into two groups, lnc-EGFRhigh and lnc-EGFRlow, according to the level of lnc-EGFR expressed, using the upper 95% confidence interval (CI) for the peripheral blood CD4 þ T cells of the volunteers as the cutoff. Analysis of their clinical characteristic revealed...
A high level of epidermal growth factor receptor (EGFR) expression in non-small cell is a good predictor for increased survival with cetuximab added to first-line , according to a major study reported at the World Conference on Lung Cancer (4 July; Amsterdam, The Netherlands). The phase III...
疗效 毒性 选择 EGFR状态作为结直肠癌的预后因素 82%的结直肠癌EGFR有不同程度的表达 与RFS相关性(%)60(n=5)75(n=4)0(n=1)与OS相关性(%)63(n=11)71(n=7)69(n=13)Frequency(%)ofstudiesshowinganassociationbetweenincreasedEGFRlevelanddecreasedsurvival 肿瘤类型 EGFR作为强烈预后指标 膀胱癌宫颈癌...
[1].Citri A, Yarden Y. EGF–ERBB signalling: towards the systems level[J]. Nature reviews Molecular cell biology, 2006, 7(7): 505-516. [2].Hynes N E, MacDonald G. ErbB receptors and signaling pathways in ca...
PLos One. 2014定量分析及动态检测血浆游离DNA EGFR T790M突变对EGFR TKI治疗的进展期NSCLC预后的研究血液EGFR检测中国专家共识Author | 00 Month YearSet area descriptor | Sub level 119第二步:突变患者,靶向先行EG 15、FR-TKI使EGFR敏感突变阳性患者显著受益21研究研究 RR 中位中位PFS(月)(月)IPASS 71.2% ...
Here we present the first comprehensive description of the genomic architecture ofEGFR-mutant LUAD through multi-region exome sequencing and SNP arrays on 16 tumors. Despite low-mutation burdens in these predominantly never-smoker oncogene-driven LUADs, we demonstrate an under-appreciated level of ge...
(a) CGH array profiles of a resistant NSCLC tumour (left) and SCLC transformed tumour (right) from Patient #7 at the level of the whole genome (top), chromosome 13q12.12-q32.2 (middle) and the 0.8 Mb region flanking the RB1 gene (bottom). The RB1 gene locus is depicted and ...