The patient-level analysis showed that responders have a better PFS and OS compared with nonresponders. A therapy in advanced NSCLC with a large magnitude... Gideon,M,Blumenthal,... - 《Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology》 被引量: 74发表...
The aim of this study was to evaluate the impact of smoking on the treatment outcome of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-T... Y Ki,Cha,H Yun,... - 《Journal of Thoracic Disease》 被引量: 2发表: 2016年 An individual patient-level meta-analysis of non–...
EGFR-IN-70 (compound 18j) is a potentSuppressed phosphorylation of the EGFR and the downstream signaling ERK level. [1]. Chen H, et, al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors ...
A high level of epidermal growth factor receptor (EGFR) expression in non-small cell is a good predictor for increased survival with cetuximab added to first-line , according to a major study reported at the World Conference on Lung Cancer (4 July; Amsterdam, The Netherlands). The phase III...
We divided the HCC patients into two groups, lnc-EGFRhigh and lnc-EGFRlow, according to the level of lnc-EGFR expressed, using the upper 95% confidence interval (CI) for the peripheral blood CD4 þ T cells of the volunteers as the cutoff. Analysis of their clinical characteristic revealed...
To characterize the clinical relationship between MCT-1 and YY1, EGFR, MnSOD and p53, the average mRNA level of each gene in normal lung tissue was defined as the threshold. For a given gene, its expression level was dichotomized into 'low' and 'high'; it was 'high' if and only if...
The observation that EGFR/ERBB2 inhibition downregulates Areg expression without affecting the TGF-β pathway suggests that this feedback is at the level of AREG, not at the level of TGF-β receptor activation. Indeed, previous studies showed that Areg is a gene target of EGFR signaling in ...
The pre-treatment level or the dynamic change of EGFR mutant abundance could help observe the course of thediseases and predict the efficacy of TKIs. TKIs resistance could be detected by change of abundance prior to image manifesta-tions. Besides, the abundance of T790M could also predict drug ...
miRNAs are well known to suppress gene expression at the posttranscriptional level and, as expected, HGF mRNA remained unchanged with the effects of miR-26a/b mimics or inhibitors (Fig. 5d). In conclusion, miR-26a and miR-26b regulate HGF expression in primary liver cells by directly ...
However, even the combination of these is likely to identify only a minority of non-responsive KRAS WT patients (Laurent-Puig et al, 2009). Unlike the EGFR protein expression level assessed by immuno- histochemistry (IHC) (Cunningham et al, 2004; Saltz et al, 2004; Chung et al, 2005),...