While the threshold is remarkably robust, a more sophisticated model predicted that it could be modulated as a function of EGFR levels on the cell surface. We confirmed experimentally that the system has evolved to perform optimally at physiological levels of EGFR. As a consequence, this system ...
In defined, serum-free medium that contained only very low concentrations of insulin (0.6 microgram/ml) and transferrin (0.6 micrograms/ml), hEGFR-virus infected cells were able to grow with EGF as the only growth factor. Moreover, daily incubation of the cells with EGF for only 30 min ...
Because epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and epidermal growth factor receptor (EGFR) have been implicated in the regulation of adrenocortical function, we used immunohistochemistry and in situ hybridization of EGF and TGF-alpha to study 41 specimens of hum...
Hypochloremia (97 mmol/l) showed an independent association with an elevated risk of all-cause mortality, even after controlling for factors such as age, co-morbidities, hyponatremia, and eGFR (HR 241, 95%CI 216-269, p<0.0001). Crude hyperchloremia, at a level of 107 mmol/L, exhibited...
2.10. Analysis of Intracellular Pathways Activity Using Bio-Plex Magnetic Assay To analyze the influence of EVs on the phosphorylation of EGFR (Y1173), extracellular-regulated kinase (ERK)1/2 (T202/Y204, T185/Y187), p38 MAP kinase (Thr180/Tyr182), c-Jun N-terminal kinase (JNK)1/2 (...
Normal value for Estimate Glomerular Filtration Rate (eGFR): Estimated Glomerular Filtration Rate (eGFR) >60 mL/min/1.73 m2 Increased blood urea nitrogen levels may indicate: Alimentary tube feeding Bladder outlet obstructions Burns Congestive heart failure Dehydration Excessive protein catabolism Excessive...
Quantitative determination of the epidermal growth factor receptor in cervical cancer and normal cervical epithelium by 2-color flow cytometry: Evidence fo... Expression of epidermal growth factor receptor (EGFR) was quantified by 2-color flow cytometry in cervical cancer (n = 73) and normal ...
Gene fusions are another class of potential oncogenic drivers in cancer, including pediatric cancers19. We observed that specific gene fusions and/or gene fusion partners were enriched in specific cancer subtypes. Adult IDH-wt glioblastoma frequently harbored gene fusions involving EGFR (17.7% of ...
She ended up on a triannual schedule, instead of her usual four scans a year — a protocol she has stuck with close to two years later. It might seem like only a small change, but “it makes a world of difference to me,” says Feldman, a co-founder of the EGFR Resisters, an ...
17,18 We subsequently used the Modification of Diet in Renal Disease Study equation to determine eGFR using the imputed creatinine levels.19 There was no difference in distribution of imputed and unimputed creatinine and corresponding eGFR values (eFigure 1 in the Supplement). Statistical Analysis ...