B cell antigen extraction is regulated by physical properties of antigen-presenting cells. J Cell Biol (2017) 216:217-30. doi:10.1083/jcb.201607064Spillane, K.M., and Tolar, P. (2017). B cell antigen extraction is regulated by physical properties of antigen-presenting cells. J. ...
Antigen-presenting cell DC: Dendritic cell NK: Nature killing AC: Apoptotic cell TLR: Toll-like receptor Type 1 IFNs: Type 1 interferon TIDC: Tumour-infiltrating dendritic cell NSCLC: Non-small cell lung cancer IHC: Immunohistochemistry AJCC: American Joint Committee on Cancer RT...
B cell activation factor (BAFF) is a novel member of the TNF ligand superfamily, mainly produced by myeloid cells. BAFF has been shown to participate in B-cell survival and B- and T-cell maturation. BAFF expression in adipocytes has been recently demonst
A) antigen-presenting cells B) plasma cells C) dendritic cells D) memory B cells Which cell type is a patient missing if a patient's immune system cannot ingest microorganisms for the purpose of presenting their antigens to the immune system and thus activatin...
During the interaction of a T cell with an antigen-presenting cell (APC), several receptor ligand pairs, including the T cell receptor (TCR)/major histocompatibility complex (MHC), accumulate at the T cell/APC interface in defined geometrical patterns. This accumulation depends on a movement of...
Eventually, many of the T helper lineage-negative cells became regulatory T cells themselves through an interleukin-2-dependent mechanism. Our results indicate that exposure to food antigens causes cognate CD4+ naive T cells to form a complex set of noncanonical hyporesponsive T helper cell subsets...
To understand the nature of the allo-HLA-DP-specific immune response provoked under different stimulatory conditions, immune responses were induced from both the naïve and memory T cell compartments using either HLA-DP-mismatched professional antigen-presenting cells (APCs) (monocyte-derived dendritic...
Interestingly, this coincides with B cell acquisition of the CD20 antigen, suggesting a mechanism whereby BCDT could act at the root of the autoimmune process. Are B cells and plasma cells present at the site of clinical disease? The finding of large numbers of B cells and plasma cells ...
Among the most notable effects, CDK4/6 inhibition induces transcriptional reprogramming in both tumor cells and immune cells to enhance tumor cell immunogenicity, promote an immune-rich tumor microenvironment, and skew T cell differentiation into a stem-like phenotype that is more amenable to immune ...
Accumulating evidence underscores the T-cell immune synapse (IS) as a site of intense vesicular trafficking, on which productive signaling and cell activation crucially depend. Although the T-cell antigen receptor (TCR) is known to exploit recycling to a