To initiate T-cell immunity, a naive T cell must first recognize a specific peptide–MHC complex (signal 1). This is an intimate interaction and the two cell types must be in close proximity to form what has been termed an ‘immunological synapse.’ Professional antigen-presenting cells expres...
摘要: Grand Challenges in Molecular Antigen-Presenting Cell-Biology 关键词: Antigen presenting cell cross-presentation dendritic cell Hematopoiesis immune cell migration immune-tolerance Immunotherapy T cell activation DOI: 10.3389/fimmu.2011.00008 被引量: 6 ...
Interdigitating dendritic cell sarcoma (IDCS) is a very rare and aggressive neoplasm that arises from antigen presenting cells. IDCS usually involves lymph... L Suk-Young,LS Ryeon,WJ Chang,... - 《Korean Journal of Hematology》 被引量: 18发表: 2012年 加载更多来源...
Facts on the fragmentation of antigens in presenting cells, on the association of antigen fragments with MHC molecules in cell-free systems, and speculation on the cell biology of antigen processing. Immunol Rev. 1988 Dec; 106 :181–... O Werdelin,S Mouritsen,B Petersen,... - 《Immunologic...
protein antigen is ingested by an antigen-presenting cell (APC), partially digested into peptide fragments and then displayed on the surface of the APC associated with an antigen-presenting molecule such as MHC class I or MHC class II, for recognition by certain lymphocytes such as T cells. ...
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments ther...
neoplastic cells. Class II products, defined by immune response (Ir) genes, are expressed principally on the membranes ofantigen presenting cells(e.g., macrophages, dendritic cells, B lymphocytes) and mediate the regulation, through so-called helper and suppressor effects, of a variety of humoral...
N. Hepatic T cells and liver tolerance. Nature Rev. Immunol. 3, 51–62 (2003). A detailed account of T cell biology in the liver and of the mechanisms that promote T cell inactivation, tolerance and apoptosis following local antigen presentation in the liver. CAS Google Scholar Tsoulfas,...
Antigen processing for presentation by antigen presenting cells (APCs) expressing class II major histocompatibility complex molecules (MHC II) involves partial digestion of antigen, binding of antigen-derived peptides to MHC II, and intracellular trafficking of both antigen and MHC II. In this thesis...
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