Keywords: iron; transcription; metal; heme; iron鈥搒ulfur cluster; transporter; yeast; starvationdoi:10.1002/9781119951438.eibc2132Caroline C. PhilpottPamela M. SmithJohn Wiley & Sons, LtdPhilpott, C., and P. Smith, 2013 The iron starvation response in Saccharomyces cerevisiae, Metals in Cells,...
同时, Fe-S簇与铁代谢息息相关, 最近研究表明, 铁硫簇缺乏可强烈地激活IRP1介导的铁-饥饿反应(iron-starvation response)并增强IRP2与靶基因的结合引发细胞铁过载, 促进细胞铁死亡[60,61]. 此外, 溶质载体家族3成员14(solute carrier family 39 member 14, SLC39A14)在转运NTBI过程中发挥重要作用[62,63].除...
Thus, NCR247 treatment leads to an iron starvation response and increase in import of iron even during iron sufficient and replete conditions. Extended Data Fig. 6 Nodules of M. sativa and M. truncatula inoculated with Δirr S. meliloti are pale and deformed. a, b, Representative image of ...
elegans in response to mitochondrial stress in a pdr-1/Parkin-, pink-1/Pink-, and dct-1/Bnip3-dependent manner. The induction of mitophagy is part of a hypoxia-like, iron starvation response triggered upon frataxin depletion and causally involved in animal lifespan extension. We also ...
(18) demonstrated that IRP1 predominantly exists in cytosolic aconitase form, while IRP2 could selectively bind to IRE in response to iron starvation. Based on the complementary role of IRP1 and IRP2 (i.e., deletion of IRP1 increases IRP2 and vice versa), neither of IRP1 nor IRP2 knock...
itory activity of 1-HP against DhapX, DsidD and DsidF, (iii) 1-HP transcriptionally induces an iron starvation response, i.e. it induces genes required for adaptation to iron starvation (HAPX, SIDA, SIDF, SIDG, MIRB) and represses genes encoding iron-dependent proteins (ACOA, CYCA) ...
DFX induces an iron-starvation response in R. oryzae and activates RFTR1 expression. Addition of DFX to cultures of different members of the Mucorales produced a fungicidal effect, which was reversed by the addition of iron. The MIC90s of DFX against various Mucor spp. were much lower than ...
In Saccharomyces cerevisiae, expression of the transcriptional activator GCN4 increases at the translational level in response to starvation for an amino a... R Cuesta,AG Hinnebusch,M Tamame - 《Genetics》 被引量: 191发表: 1998年 加载更多来源...
The heme-responsive PrrH sRNA regulatesPseudomonas aeruginosapyochelin gene expression (2023)https://doi.org/10.1128/msphere.00392-23 The human innate immune protein calprotectin elicits a multi-metal starvation response inPseudomonas aeruginosa(2021)https://doi.org/10.1128/Spectrum.00519-21 ...
[126], whereas IRP2 is regulated by ubiquitin-dependent proteasomal degradation mediated by the ISC-containing protein FBXL5 [127]. Interestingly, inhibition of ISC synthesis was recently shown to promoteferroptosisvia the IRP-mediated activation of the iron-starvation response [67,128]. Even though...