Juvenile hemochromatosis and nonalcoholic steatohepatitis (NASH) related iron overload are the genetic and secondary causes, respectively.Observations:Both patients benefited from phlebotomy even if they had different etiologies.Conclusions:In childhood, the diagnosis of iron overload syndromes is crucial ...
Mild to moderate iron overload (1–2+) generally correlates with quantitative iron values between 3000 and 10 000 μg Fe/g dry weight liver (Figure 2). Grades 3 and 4 iron histologically generally reflect >10 000 μg Fe/g dry weight liver (Figure 3). In uncomplicated HH, mos...
iron overload have abnormal liver function tests that are not obviously related to any other complication of HCT,1312,1317and in some cases these can clinically mimic other conditions (e.g. GVHD).1311,1318Liver biopsy is helpful in these patients, both to confirm the severity of iron over...
The baboon appeared to be a useful model for the study of iron overload. Although in this study most of the damage was reversible, it is suspected that more prolonged overload, a different route of administration or other, more toxic iron compounds, may lead to cirrhosis similar to that ...
Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Lucarelli G: Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone ...
Iron chelators have been widely used to remove excess toxic iron from patients with secondary iron overload. However, small molecule-based iron chelators can cause adverse side effects such as infection, gastrointestinal bleeding, kidney failure, and liv
Survival after orthotopic liver transplant (OLT) among patients with hepatic iron overload: interim results from the national hemochromatosis transplant registry (NHTR): Kris V Kowdley, University of Washington, Seattle, WA; David J Brandhagen, Mayo Clinic, Rochester; Robert G Gish, CA Pacific ...
The effect of iron overload on rat plasma and liver oxidant status in vivo. AJ Dabbagh,T Mannion,SM Lynch,... - 《Biochemical Journal》 被引量: 0发表: 1994年 The effect of iron overload on rat plasma anti liver oxidant status in vivo Tl_ere i5 ample evLdence The effect of iron ...
transporter that complemented a Δccc1yeast strain14,15,16. Deletion of VIT inPlasmodiumdemonstrated that the gene was essential for replication in both blood and liver stage parasites. Further, the absence of VIT renderedPlasmodiummore susceptible to iron overload and more resistant to iron removal...
Hereditary hemochromatosis is an iron overload disorder that can lead to the impairment of multiple organs and is caused by mutations in one or more different genes. Type 1 hemochromatosis is the most common form of the disease and results from mutations in the HFE gene. Juvenile hemochromatosis...