Iron overload, hfe gene mutations and insulin resistance in non alcoholic fatty liver disease (NAFLD)collagen genetranscriptional regulationhepatic fibrogenesisTGF betaSmadIncreased production of type I collagen is a common hallmark of fibrotic diseases in various organs including the liver. This increase...
The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general population, as is detected in about one third of patients with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome. The pathogenesis is related to altered regulation of iron transport associated...
and serum uric acid levels indicating insulin resistance, but not indices of iron overload, are independent predictors of non-alcoholic fatty liver disease... A.,Lonardo,and,... - 《Digestive & Liver Disease》 被引量: 331发表: 2002年 Iron Metabolism in Nonalcoholic Fatty Liver Disease Non...
Nonetheless, iron overload is more commonly observed in obese individuals, who are more susceptible to fatty liver disease [8]. Excess ferrous ions (Fe2+) generate large amounts of toxic reactive oxygen species (ROS) through the Fenton reaction [9]. These ROS directly cause damage to cellular...
Fatty liver was defined as hepatic PDFF >5.6% based on MRS; only subjects with fatty liver were considered for analyses involving fat. From a group of 40 patients with known/suspected iron overload, nine patients were identified at 1.5T, and 13 at 3.0T with fatty liver. MRS linewidth ...
The mechanism by which iron excess in the liver affects glucolipid metabolism, however, is yet unknown. This study set out to see if iron overload might impact the development of obesity and the chronic conditions that come with it. 2. Materials and Methods 2.1. Animal Experiments The ...
Iron accumulation in the liver causes scarring of the liver (cirrhosis) and an increased risk of developing liver cancer. Hereditary hemochromatosis is an inherited (genetic) disorder in which there is excessive accumulation of iron in the body (iron overload). It is a common genetic disorder ...
Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. G,D,McLaren,... - 《Critical Reviews in Clinical Laboratory Sciences》 - 1983 - 被引量: 261 Iron and non-alcoholic fatty liver disease...
Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver ir...
Correlation analysis included complete data from patients with nonalcoholic fatty liver disease with (n = 21) and without (n = 22) iron overload and control subjects (n = 16; all subjects combined, n = 59). FP1, ferroportin 1 mRNA expression; HJV, hemojuvelin mRNA expression; TfR-1, tra...