Iron overload (IO) and severity of liver disease in chronic hepatitis C (CHC) patientsfatty liverHTKischemiamarginal donormitochondriaoxygen persufflationpreservationsteatosistransplantationVSOPBackground/Aims: The incidence of steatosis in livers retrieved for organ transplantation is up to 30%, Due to ...
Hemochromatosis(iron overload) is a metabolic disorder that leads to abnormally elevated iron stores in the body. The excess iron may accumulate in the tissues of the liver, pancreas, and heart, which can lead to inflammation, cirrhosis, liver cancer, and liver failure. Hemochromatosis is aninhe...
Iron overload in liver disease not associated to hemochromatosis is increasingly recognized in cirrhosis. The aim was to evaluate the relationship between iron overload and the main underlying pathophysiological mechanisms of cirrhosis: liver insuffiency and portal hypertension. Methods:All consecutive ...
Alcoholics who were heterozygotes for H63D mutation and had evidence of iron overload, showed an even greater risk of developing liver disease [odds ratio 2.17 (95% CI 1.42-3.32)]. Based on these findings, it appears that iron overload is an important co-factor in the development of ...
Approximately one third of patients with non-alcoholic fatty liver disease (NAFLD) show signs of disturbed iron homeostasis as indicated by elevated serum ferritin with normal or mildly elevated transferrin saturation. Mild hepatic iron deposition is the typical histological finding in these subjects and...
liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism. Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the bloodstream. ...
Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of liver disease in a cohort of... VD Marco,M Capra,F Gagliardotto,... - 《Haematologica》 被引量: 72发表: 2008年 Iron overload-induced rat liver injury: Involvement ...
> Section > Chapter Arthur, M.J. Journal of Gastroenterology and Hepatology 11(12): 1124-1129 1996 ISSN/ISBN:0815-9319 9034931 10.1111/j.1440-1746.1996.tb01840.x 008918426 Article emailed within 0-6 h Buy Now for$19.90 Payments are secure & encrypted ...
Objectives: The purpose of this prospective study was to evaluate the accuracy of inphase and out-of-phase imaging to assess hepatic iron concentration in patients with haematological malignancies and chronic liver disease. Methods: MRI-based hepatic iron concentration (M-HIC, μmol g-1) was used...
alcoholic liver disease, porphyria cutanea tarda), and liver-specific iron accumulation of uncertain pathogenesis in cirrhosis. The anatomic pathologist will be faced with the task of determining whether iron accumulation in the liver is significant and, if so, the nature of the disease that lead ...