Current knowledge about chronic pancreatitis (CP) is limited and there is a particular dearth of information about the entity known as tropical pancreatitis. A consensus working party was convened by the Trustees of the Journal of Gastroenterology and Hepatology Foundation to conduct a systematic ...
As the main organ of storing excess iron,liver is the first target organ damage when iron overload.However,the relation between nonalcoholic fatty liver disease and iron overload is still controversial.More and more studies have shown that iron overload in the development of nonalcoholic fatty ...
Mild hepatic iron deposition is the typical histological finding in these subjects and the term "dysmetabolic iron overload syndrome (DIOS)" is now used to describe this syndrome. From a clinical point of view, excess iron likely aggravates the natural course of NAFLD with regard to liver-...
The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general population, as is detected in about one third of patients with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome. The pathogenesis is related to altered regulation of iron transport associated...
Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states. This condition can lead to significant health complications and may pose life-threatening...
and hepatitis C viral infection. Chronic liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism. Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-tra...
Chronic liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism. Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-transferrin-bound iron in the ...
LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non-alcoholic fatty liver disease. J. Cell. Mol. Med. 25, 7354–7366 (2021). Article CAS PubMed PubMed Central Google Scholar Cross, A. J. et al. Iron homeostasis and distal colorectal adenoma risk...
foriron-loadedanemiaarealsoimportant cofactorswhichinfluencethebackgroundironoverload. Furthermore,thereisaccumulatingevidencesthatfatty acidaccumulationwithoutalcoholandobesityitself modifiesinsulinresistancethroughiron [2] andfibrogenesis oftheliver [3] .Inthisreview,theroleofcofactorson ironoverloadwill...
Mild iron overload is frequently observed in nonalcoholic fatty liver disease (NAFLD).We aimed to study putative pathways underlying iron accumulation in NAFLD.Hepatic and duodenal expression of critical iron molecules in NAFLD patients with (n = 32) and without (n = 29) iron overload, ...