Current knowledge about chronic pancreatitis (CP) is limited and there is a particular dearth of information about the entity known as tropical pancreatitis. A consensus working party was convened by the Trustees of the Journal of Gastroenterology and Hepatology Foundation to conduct a systematic ...
The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general population, as is detected in about one third of patients with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome. The pathogenesis is related to altered regulation of iron transport associated...
Mild hepatic iron deposition is the typical histological finding in these subjects and the term "dysmetabolic iron overload syndrome (DIOS)" is now used to describe this syndrome. From a clinical point of view, excess iron likely aggravates the natural course of NAFLD with regard to liver-...
Fatty liver diseaseis usually the first changes to be seen with long term alcohol misuse. With severe abuse, fatty liver may progress toalcoholic hepatitiswhich is the acute inflammation of the liver induced by alcohol. However, alcoholic hepatitis can also arise in the previously normal liver if...
be associated with extrahepatic manifestations such as cardiovascular disease, T2DM, chronic kidney disease, extrahepatic malignancies (e.g., colorectal cancer), endocrine diseases (e.g., hypothyroidism, polycystic ovarian syndrome, psoriasis, and osteoporosis), obstructive sleep apnea, and iron overload...
Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe Hepcidin is a hormone central to the regulation of iron homeostasis in the body. It is believed to be produced exclusively by the liver. Ferroportin, an ir... J Gnana-...
BACKGROUND: Research suggests the presence of mild-to-moderate iron overload in patients with nonalcoholic fatty liver disease (NAFLD). The role played by hepcidin, the master regulatory hormone of systemic iron metabolism, in the pathogenesis of NAFLD remains controversial. The aims of this study...
miR-34a regulates lipid metabolism by targeting SIRT1 in non-alcoholic fatty liver disease with iron overload Background Micro-ribonucleic acids (miRNAs) have been implicated in the regulation of non-alcoholic fatty liver disease (NAFLD), a leading cause of chronic... L Wang,M Sun,Y Cao,.....
Mild iron overload is frequently observed in nonalcoholic fatty liver disease (NAFLD). Objective We aimed to study putative pathways underlying iron accumulation in NAFLD. Design Hepatic and duodenal expression of critical iron molecules in NAFLD patients with (n = 32) and without (n = 29) iron...
Iron overload as a risk factor for hepatic ischemia–reperfusion injury in liver transplantation: potential role of ferroptosis Am J Transplant, 20 (2020), pp. 1606-1618 View PDFView articleGoogle Scholar 50 Z. Kong, R. Liu, Y. Cheng Artesunate alleviates liver fibrosis by regulating ferroptosi...