Iron overload in the liver can aggravate ethanol-elicited liver damage by potentiating oxidative stress via Fenton reaction, promoting activation of Kupffer cells (KCs) and hepatic stellate cells (HSCs), and inducing a recently discovered programmed iron-dependent cell death, ferroptosis. This article...
Altered elimination pathways for BA and cholesterol may interfere with the pathophysiology of liver damage accompanying liver diseases with excessive iron deposition.doi:10.1038/s41598-019-46150-7Scientific reports
Hemochromatosis(iron overload) is a metabolic disorder that leads to abnormally elevated iron stores in the body. The excess iron may accumulate in the tissues of the liver, pancreas, and heart, which can lead to inflammation, cirrhosis, liver cancer, and liver failure. Hemochromatosis is aninhe...
A new study suggests that exposure to the controversial weedkiller Roundup just before birth may increase the risk of liver damage, due to iron overload. Brazilian researchers found that perinatal Roundup exposure can lead to an iron overload, which causes oxidative damage to the unborn child’s...
Excess iron has long been postulated as a risk factor for developing liver fibrosis and cirrhosis, and recently direct evidence has emerged with respect to the pathogenic role of ferroptosis in iron overload-induced liver damage and fibrosis [14]. However, the precise function of iron-regulating ...
Iron overload and liver function in patients with beta thalassemia major: A cross sectional study Objective: In thalassemia major, repeated blood transfusions result in iron overload causing organ damage. The objective of this study was assessment of li... Faruqi, Amna,Zafar, Tooba,Subuctageen,...
The baboon appeared to be a useful model for the study of iron overload. Although in this study most of the damage was reversible, it is suspected that more prolonged overload, a different route of administration or other, more toxic iron compounds, may lead to cirrhosis similar to that ...
> Section > Chapter Arthur, M.J. Journal of Gastroenterology and Hepatology 11(12): 1124-1129 1996 ISSN/ISBN:0815-9319 9034931 10.1111/j.1440-1746.1996.tb01840.x 008918426 Article emailed within 0-6 h Buy Now for$19.90 Payments are secure & encrypted ...
Relationship between iron overload and nonalcoholic fatty liver disease As the main organ of storing excess iron,liver is the first target organ damage when iron overload.However,the relation between nonalcoholic fatty liver di... T Peng - 《Chinese Journal of Gastroenterology & Hepatology》 被...
hemochromatosis(iron overload), shock, and/or heart failure. Common causes of abnormal AST and ALT levels are wide-ranging (for example, toxins, and autoimmune diseases). Many drugs may cause elevated blood levels of AST, and ALT and some medications can cause severe damage, for example, ace...