IRON metabolismCOLORECTAL cancerIRON in the bodyIRONIRON deficiencyIron, as one of the essential trace elements in the human body, is involved in a wide range of critical biochemical reactions and physiological processes, including the maintenance of the normal cell cycle, mitochondrial function, ...
Iron Metabolism in Cancer Progression Iron is indispensable for cell metabolism of both normal and cancer cells. In the latter, several disruptions of its metabolism occur at the steps of tumor... S Forciniti,L Greco,F Grizzi,... - 《International Journal of Molecular Sciences》 被引量: 0...
. J Cancer Ther 2012; 3: 278-311. status of extracellular antioxidant system. Cytology 2013; 5: 307-11 (in Russian).Elliott R, Head J (2012) Cancer: Tumor iron metabolism, mitochondrial dysfunction and tumor immunosuppression; “A tight partnership–was Warburg correct?” . Journal of ...
The same set of mice studies revealed that doxorubicin, a drug used to treat common cancers such as breast and bladder cancer, increases the activity of a gene Hmox-1 in heart cells. The gene codes for an enzyme ...
Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer...
Based on these data, we searched to identify if iron metabolism pathway is deregulated in DLBCL and could be exploited to develop novel therapeutic strategies. A list of 63 genes related to iron metabolism in cancer was defined. Using Maxstat R function, we showed that 12 genes out of the ...
In this review, we select relevant and promising studies in the field of iron metabolism in cancer research and clinical oncology. Besides this, we discuss some co-existing discrepant findings. We also present and discuss the latest lines of research related to targeting iron, or its regulatory ...
iron metabolism is a key function for a tumour cell. In fact, it has been shown that downregulation of both the iron storage protein ferritin and the iron exporter ferroportin (FPN), together with increased TfR1 expression, leads to higher iron availability in a variety of cancer cells ...
and then the medical importance is its role in cancer," he said. "It looks like MEMO1 makescancer cellsmore sensitive to disruptions of iron distribution, so the practical upshot is that we can use iron metabolism in the cell as a target to kill cancer cells." ...
Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer...