Further research is warranted to better understand the complex relationship between dietary iron, physiological iron and cancer development. Future research should account for factors that affect and interact with dietary iron and physiological iron levels, such as genetic susceptibili...
Other iron-regulatory proteins, such as IRP1 and IRP2, contribute to cancer in ways that are less well understood. Iron is crucial to many fundamental cellular processes, including DNA synthesis, proliferation, cell cycle regulation and the function of proteins containing iron–sulphur clusters. ...
Our data reveal a critical function of iron-dependent H3K9 demethylation in B-cell proliferation and establish a link between iron and humoral immunity. Results The iron levels in serum correlate with antibody responses to vaccination in humans First, we sought to determine whether humoral immunity ...
Recent studies suggest that elevated body iron levels may contribute to breast carcinogenesis; however, epidemiologic evidence is lacking. We used data from a large cohort study of Canadian women to assess breast cancer in association with total iron and heme iron intake. Among 49,654 women ages ...
Serum Iron Levels Decreased in Patients with HBV-Related Hepatocellular Carcinoma, as a Risk Factor for the Prognosis of HBV-Related HCC 来自 学术范 喜欢 0 阅读量: 94 作者:Y Wei,Y Wei,W Zhao 摘要: Background:Hepatocellular carcinoma (HCC) is common and the second leading causes of cancer-...
Increased endogenous DNA oxidation correlates to increased iron levels in melanocytes relative to keratinocytes. The endogenous oxidative state of normal human epidermal melanocytes was investigated and compared to normal human epidermal keratinocytes (NHEKs) in order to gain new insight into melanocyte ...
"It's clear that iron is playing a critical role in controlling the development of bowel cancer in people with a faulty APC gene. And, intriguingly, our study shows that even very high levels of iron in the diet don't cause cancer by itself, but rely on the APC gene." Co-author Dr...
Nail iron levels were measured in 300 cases and 300 controls using neutron activation analysis. A total of 24 genetic variants associated with iron status were genotyped in 622 cases and 628 controls. Logistic regression was used to estimate odds ratios (OR) and 95 % confidence intervals (CI)...
Dr. Dipender Gill, from Imperial's School of Public Health and who supervised the study, said: "We have known for a long time that having too much or too little iron in your system can have serious impacts on your health, and that effectively modifying iron levels can help many people ...
Other iron-regulatory proteins, such as IRP1 and IRP2, contribute to cancer in ways that are less well understood. Iron is crucial to many fundamental cellular processes, including DNA synthesis, proliferation, cell cycle regulation and the function of proteins containing iron–sulphur clusters. ...