Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of ...
Dysregulation of iron metabolism can increase cancer risk and promote tumor growth. Cancer cells exhibit an enhanced dependence on iron relative to their normal counterparts, a phenomenon we have termed iron addiction. Work conducted in the past few years has revealed new cellular processes and ...
The protective effects of AMF and/or its metabolites on DNA alkylation or free radical induced DNA damage not only have implications on acute cytotoxic ... PLG Korkina - 《Cancer Causes & Control》 被引量: 39发表: 2000年 Effects of cytosine arabinoside on human leukemia cells. Cytosine arabin...
Infants and children, especially those born prematurely or experiencing a growth spurt Cancer patients People with heart failure People who have gastrointestinal disorders or have had gastrointestinal surgery Vegetarians who don’t replace meat with another iron-rich food ...
Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis Background Young women diagnosed with breast cancer are known to have a higher mortality rate from the disease than older patients. Specific risk factors l... ...
[41,42]. The mechanisms of ferroptosis include iron overload, lipid peroxidation, abnormal GSH–GPX4–ROS pathway, cancer suppressor gene P53 (P53), NADPH/ferroptosis inhibitory protein 1/coenzyme Q10 (NADPH/FSP1/CoQ10) pathway, and oxidative stress. These mechanisms lead to the accumulation of...
Salusky IB: Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild type and hepcidin knockout mice. ... K Chua,M Rappaport,D Goltzman,... - 《American Journal of Physiology》 被引量: 6发表: 2016年 Effects of polysaccharide fromAngelica ...
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496, 101–105 (2013). Article CAS PubMed PubMed Central Google Scholar Maddocks, O.D. et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493, 542–...
et al. Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nat. Nanotechnol. 11, 977–985 (2016). Article CAS Google Scholar Riegman, M. et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat...
The regulation of iron metabolism is altered in tumour cells. Changes in iron regulation enhance iron influx and retention. This leads to altered cellular processes that foster cancer growth and metastasis, and provides an opportunity for the development