Anemia is a prevalent complication in patients with cancer, both at diagnosis and during treatment, with notable negative effects on quality of life and overall prognosis. Iron deficiency is the most common cause of anemia in the patients and can affect almost half of patients with solid and ...
They upregulate proteins that are involved in iron uptake, such as transferrin receptor 1 (TFR1), STEAP proteins and lipocalin 2 (LCN2), and decrease the expression of iron efflux proteins, such as ferroportin. Other iron-regulatory proteins, such as IRP1 and IRP2, contribute to cancer in ...
Background Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified. Methods One candidate is iron deficiency, as this ...
Iron deficiency (ID) and anaemia are frequent complications in cancer patients, in particular during treatment with chemotherapeutic agents [1., 2., 3.]. ID, even in the absence of anaemia, may be associated with impaired physical function, weakness, and fatigue that can be ameliorated by iro...
Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia Only limited data on the prevalence of iron deficiency (ID) and its correlation with clinical parameters are available in cancer. ID frequently contributes... H Ludwig,E ...
Table 3. Benefit-risk profiles of treatments for anaemia and ID in cancer patients Empty CellBenefitsRisks or limitations ESAs i.v. ironb RBC transfusions CRP, C-reactive protein; ESA, erythropoiesis-stimulating agent; Hb, haemoglobin; ID, iron deficiency; i.v., intravenous; PRCA, pure red ...
摘要: e18751Background: Iron deficiency anemia (IDA) is a common condition in cancer patients (pts) and can have a deleterious effect on their outcomes. Pts with hepatocellular carcinoma (HCC) often have...DOI: 10.1200/JCO.2018.36.15_suppl.e18751 年份: 2018 ...
Iron deficiency anaemia: its effect on transfer factor for the lung (diffusing capacity) and ventilation and cardiac frequency during submaximal exercise. Clin Sci 1972;42:325-35.Willison, JR. DuBoulay, G.H., Pal, BA., Russel, R... ...
iron deficiency; iron deficiency anemia; celiac disease; malabsorption; micronutrient deficiencies; gluten-free diet; iron oral; iron intravenous; patient-blood management (PBM)1. Introduction Iron is an essential nutrient to life, and its role in biology is enormous [1,2,3]. In fact, iron is...
The regulation of iron metabolism is altered in tumour cells. Changes in iron regulation enhance iron influx and retention. This leads to altered cellular processes that foster cancer growth and metastasis, and provides an opportunity for the development