In vitroIRG1-IN-1(化合物6)在0.5 mM至2 mM的剂量下,能减少LPS激活的人源单核细胞衍生的巨噬细胞(hMDMs)产生的丁烯二酸和肿瘤坏死因子α(TNFα)的分泌[1]。在0.5 mM至1 mM的浓度,IRG1-IN-1抑制C-IRG1-9大鼠胶质瘤细胞的增殖[1]。IRG1-IN-1在10 nM的剂量下,能增强TCR激活的hCD8+ T细胞的增殖...
IRG1-IN-1 是衣康酸衍生物。IRG1-IN-1 可以抑制免疫反应基因 1 (IRG1) 的活性。IRG1-IN-1 可用于癌症、炎症和自身免疫性疾病的研究。 详细介绍 产品活性:IRG1-IN-1 是衣康酸衍生物。IRG1-IN-1 可以抑制免疫反应基因 1 (IRG1) 的活性。IRG1-IN-1 可用于癌症、炎症和自身免疫性疾病的研究。
IRG1-IN-1,CAS:2407652-42-8,IRG1-IN-1 是衣康酸衍生物。IRG1-IN-1 可以抑制免疫反应基因 1 (IRG1) 的活性。IRG1-IN-1 可用于癌症、炎症和自身免疫性疾病的研究。
Frontiers in Immunology:杨菲/李纤团队揭示IRG1/衣康酸对神经性疼痛的镇痛作用及相关分子机制 2022年10月,首都医科大学等单位的相关研究人员在《Frontiers in Immunology》(IF: 8.8)上发表了题为“IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve in...
Chestnut Studying 摘要 Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly …
Immune response gene 1 (IRG1) is highly expressed in mitochondria of macrophages in a pro-inflammatory state. IRG1 and its metabolites play important roles in infection, immune-related diseases and tumor progression by exerting resistance of pathogens, attenuating inflammation and producing antioxidant ...
Interestingly, the expression of IRG1 was up‐regulated in hepatocytes after I/R and hypoxia/reoxygenation (H/R)﹊nduced oxidative stress. Modulation of the IRG1 expression levels in hepatocytes regulated hepatocyte cell death. Importantly, addition of 4﹐ctyl itaconate (4㎡I) significantly ...
Itaconate is produced from the mitochondrial TCA cycle enzyme aconitase decarboxylase (encoded by immune responsive gene1; Irg1) that exerts immunomodulatory function in myeloid cells. However, the role of the Irg1/itaconate pathway in dendritic cells (DC)-mediated airway inflammation and adaptive immu...
Consequently, the activation of the ACOD1 pathway is implicated in regulating the pathogenic process of sepsis and septic shock, which are part of a clinical syndrome of life-threatening organ failure caused by a dysregulated host response to pathogen infection. In this review, we discuss the ...
dTHP1 cells were incubated for 6 or 24 h with different concentrations of itaconate (0.125, 5, 10 and 25 mM), mesaconate or citraconate (5, 10, and 25 mM) in 1 ml of RPMI. After complete removal of medium and careful washing (one to three times) of cells and well bord...