摘要 Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the vasculature that drives plaque formation. Therapeutic approaches to reverse atherosclerotic inflammation are needed to address the rising global burden of cardiovascular disease (CVD). Recently, metabolites have gained...
大家好,本周给大家分享一篇最近发表在 PNAS 上的文章,本文的题目是“The IRG1–itaconate axis protects from cholesterol-induced inflammation and atherosclerosis”。本文的核心是作者们发现衣康酸能够降低动脉硬化心血管疾病所伴随的炎症反应...
Background: Macrophages are innate immune cells whose phagocytosis function is critical to the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene 1 (Irg1) and its metabolic product itaconate inhibit bacterial infection, intracellular viral replication, and inflammation in...
Atherosclerosis, the major underlying cause of cardiovascular disease (CVD) mortality, is fueled by a failure to resolve lipid-driven inflammation within the vessel wall. Understanding the immunometabolic mechanisms underpinning sustained inflammation within this microenvironment is needed for the development ...
Description IRG1-IN-1 is an itaconic acid derivative with the ability to inhibit the activity of Immune Response Gene 1 (IRG1) and is suitable for use in the field of cancer, inflammation and autoimmune disease research. In vitro IRG1-IN-1(化合物6)在0.5 mM至2 mM的剂量下,能减少LPS激活...
However, the role of the Irg1/itaconate pathway in dendritic cells (DC)-mediated airway inflammation and adaptive immunity to inhaled allergens, which are the primary antigen-presenting cells in allergic asthma, remains largely unknown. House dust mite (HDM)-challenged Irg1−/− mice displayed...
Exogenous itaconate promoted the efferocytosis of macrophages in IRG1f/fLyz2-cre+ mice treated with Con A (Supplement Fig. 3G-H).Taken together, IRG1/itaconate axis aggravates or attenuates Con A-induced liver inflammation by regulating efferocytosis. Fig. 5 IRG1/ itaconate axis enhances ...
inflammation by inhibiting succinate dehydrogenase (SDH) activity or alkylating cysteine residues of multiple proteins [19,21]. Meanwhile, we also found the upregulated IRG1 in macrophages during sepsis, which increased A20 expression through ROS to strengthen endotoxin tolerance [22]. A recent study...
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibitimmune-responsive gene 1 (IRG1)activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases[1]. IRG1-IN-1(compound 6) (0.5 mM; 2 mM) reduces production of itaconic acid and the sec...
Inflammation Metabolism Disease Introduction The innate immune system is comprised of different components, including various immune cells (e.g., macrophages, monocytes, dendritic cells [DCs], and neutrophils), which can rapidly recognize invading pathogens through pattern recognition receptors (PRRs). The...