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Calcium ChannelsInositol 1,4,5-Trisphosphate ReceptorsThere is substantial evidence that Ca2+ fluxes occur during most forms of apoptosis, and that inhibiting such fluxes protects cells from death. IP3 receptors – ligand-gated channels that release Ca2+ from intracellular stores – are emerging as ...
蛋白别名:inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor, type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor ...
蛋白别名: inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor, type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor...
牛内质网核心信号1(IRE1)ELISA测试盒 Bovine inositol-requiring enzyme 1 (IRE1)ELISA Kit 试剂盒别称:Hv1; VSOP; Voltage Sensor Domain-Only Protein; Hydrogen voltage-gated channel 1 规格:48人份/96人份 牛补体因子H相关蛋白1(CFHR1)ELISA测试盒 Bovine Complement Factor H Related Protein 1 (CFHR1)EL...
The TMD of IP3Rs has the same overall architecture of voltage-gated ions channels with a central pore domain, consisting of S5, S6, and pore (P) helix, surrounded by pseudo-voltage-sensor domains (pVSDs), consisting of S1, S2, S3, and S4 helices along with two IP3R/RyR specific TM...
IP3Rs are tetramers that act as ligand-gated channels facilitating Ca2+ release from internal stores/endoplasmic reticulum. The primary structure of the IP3R contains 3 domains: an Inositol triphosphate binding domain near the N terminus, a coupling domain in the middle of the molecule, and a ...
IP3Rs are tetramers that act as ligand-gated channels facilitating Ca2+ release from internal stores/endoplasmic reticulum. The ligand-gated channels facilitating Ca2+ release from internal stores/endoplasmic reticulum. The primary ...
Although defects in intracellular calcium homeostasis are known to play a role in the pathogenesis of Parkinson’s disease (PD), the underlying molecular mechanisms remain unclear. Here, we show that loss of PTEN-induced kinase 1 (PINK1) and Parkin leads
近年来,逐渐有学者已证实ER这一细胞内重要钙库对DAI后钙超载形成的作用,DAI后由于机械外力对轴膜的牵拉,导致神经元电压门控钠通道(voltage-gated sodium channels, NaCh)功能异常,导致持续的钠离子内流入细胞[9]。在这种持续的NaChs的非失活状态下,病态的钠离子内流导致持续的细胞去极化状态,从而开放了电压门控...