(2006) GIRK channel activation involves a local rearrangement of a preformed G protein channel complex . Neuron 51 , 561–573 [ PubMed ]Riven I., Iwanir S., Reuveny E. (2006). GIRK channel activation involves a local rearrangement of a preformed G protein channel complex . Neuron 51 ,...
The locations of the A, B1 and B2 elements are denoted. d The protein-DNA contacts observed in the Mcm2/Mcm5 region of the closed-gate OCCM. Positively-charged residues, thought to electrostatically interact with DNA and facilitate ring closure, are shown in blue. Full size image The O...
As each of the SDV and plasma membranes carry out specialized, different tasks, it is likely that both require unique lipid and protein compositions, which would need to be adjusted after fusion. Indeed, it has been shown that T. pseudonana cells with SDVs have a slightly altered lipid ...
Using genome-wide cDNA screening, we identify three accessory proteins, β-anchoring and -regulatory protein (BARP), lysosomal-associated membrane protein 5 (LAMP5), and SULT2B1, that complement the nACh receptor chaperone NACHO to reconstitute α6β2β3 channel function. Whereas NACHO mediates ...
coli RNAP. In the primary inhibition mechanism, Gp2 forms a protein-protein interaction with sigma(70)(1.1), preventing the normal egress of sigma(70)(1.1) from the RNAP active site channel. Gp2 thus misappropriates a domain of the RNAP holoenzyme, sigma(70)(1.1), to inhibit the ...
These results demonstrate that 20-HETE plays a significant role in the renal microvascular smooth muscle cell [Ca2+]i response to P2X receptor activation. 展开 关键词: R(-)-efonidipine T-type Ca2+ channel cardiomyocyte DOI: 10.1124/jpet.104.070797 被引量: 48 ...
Previous studies have indicated that activation of Gq‐protein coupled α1ARs generates inositol trisphosphate (IP3) and Ca2+ in the SMCs, which can be transported to the ECs through myoendothelial gap junctions. This results in an increase in EC Ca2+ thereby generating a dilatory signal that ...
The adenosine A2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify inhibitors of the A2B receptor and evaluated their effect on adenosine-induced intestinal fluid secretion. Th
cAMP-response element-binding protein DAG: diacylglycerol ERK: extracellular signal-regulated protein kinase HIV-1: human immunodeficiency virus-1 HAD: HIV-1-associated dementia IP3: inositol triphosphate MAP-2: microtubule-associated protein-2 MTT: 3(4,5-dimethylthiazol-2-yl)-2.5 diphenyl...
In isolated cerebral myocytes, BK current magnitude was reversibly increased by sodium nitroprusside (SNP, 100 μM) and sensitive to the BK channel inhibitor, penitrem-A (100 nM). Fostriecin (30 nM), a protein phosphatase type 2A (PP2A) inhibitor, significantly prolonged the SNP-induced ...