Invariant NKT (iNKT) cells recently were classified into NKT1, NKT2, and NKT17 lineages with distinct transcription factor and cytokine profiles, but the mechanisms underlying such fate decisions remain elusive. In this article, we report crucial roles for mechanistic target of rapamycin (mTOR) ...
iNKT细胞已被分为三种功能不同的亚群,即产生IFN-γ的NKT1、产生IL-4的NKT2和产生IL-17的NKT17细胞,分别表达不同的转录因子,T-bet、GATA3和RORγt。研究人员发现C2类iNKT细胞是NKT1细胞,可能对1型免疫很重要。 对dRNA-seq获得的基因组图谱进行主成分分析(PCA)的结果表明,C2型iNKT细胞表现出更多的NK细胞或先...
Here, we show that invariant NKT cells inhibited the differentiation of CD4+ T cells into Th17 cells both in vitro and in vivo. The number of IL-17-producing CD4+ T cells was reduced following co-culture with purified NK1.1+TCR+ cells from WT, but not from CD1d/ or J18/, mice. Co...
Invariant NKT (iNKT) cells recently were classified into NKT1, NKT2, and NKT17 lineages with distinct transcription factor and cytokine profiles, but the mechanisms underlying such fate decisions remain elusive. In this article, we report crucial roles for mechanistic target of rapamycin (mTOR) sig...
Invariant NKT cells (iNKT cells), which are essential bridges between the innate and adaptive immune systems, can be rapidly activated by their agonists and, consequently, evoke whole immune systems. Herein, we conjugated a potent agonist of the iNKT cell, α-galactosylceramide (α-GalCer), ...
Invariant NKT cells (iNKT cells), which are essential bridges between the innate and adaptive immune systems, can be rapidly activated by their agonists and, consequently, evoke whole immune systems. Herein, we conjugated a potent agonist of the iNKT cell, α-galactosylceramide (α-GalCer), ...
ActaBiochimBiophysSin(2008)|Volume40|Issue5|Page381NKTcellsandCD4+CD25+TregulatorycellsActaBiochimBiophysSin(2008):381-390|©2008Insti..
iNKT cells differentiate into functional subsets defined as NKT1, NKT2 and NKT17, characterized by their expression of transcription factors, T-bet, GATA3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. In our earlier studies, we showed that the transcriptional repressor...
NKT cells This article is cited by Super-enhancer omics in stem cell Hongying Ma Jian Qu Qiang Qu Molecular Cancer(2024) The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences Mandy I. Cheng Joey H. Li Maureen A. Su ...
cells is tightly regulated throughout development and settings of type-2 inflammation TF O'Brien1, K Bao1, M Dell'Aringa1, WXG Ang2, S Abraham2 and RL Reinhardt1 Invariant natural killer T (iNKT) cells produce cytokines interleukin-4 (IL-4) and IL-13 during type-2 inflammatory responses...