The function of NK cells is regulated by a fine balance of inhibitory and activating signals, which are mediated by a diverse array of cell-surface receptors. Natural killer (NK) and natural killer T (NKT) cells represent unique lymphoid subsets of the innate immune system that are both ...
Natural killer (NK) and natural killer T (NKT) cells are two important cell subsets of the innate immune system. NK and NKT cells share many phenotypes and functions for anti-tumor immunity; however, the dynamic changes in phenotypes and functional inter
representing one of best models of innate immune response, decreases in aging as well as interferon-γ (IFN-γ) production by both activated types of cells. Both NK and NKT cell cytotoxicity and IFN-γ production increase
NK, γδ T and NKT cells bridge innate and adaptive responses because although they are of the T cell lineage, they recognize antigens less specifically than αβ T cells, have rapid effects on pathogens, and secrete cytokines influencing B cells and αβ T cells. NK cell activation is con...
with Advanced Hepatocellular Carcinoma Treated with Adoptive Cell Therapy Using Natural Killer Cells: ...
NK细胞的数量和功能会随着年龄的增长而发生变化。在衰老过程中，虽然大多数淋巴细胞的数量会降低，但NK细胞却是个例外。研究表明，随着年龄的增长，NK细胞和NKT细胞的数目会明显增加。这可能是因为随着年龄的增长，外周血前体细胞的淋巴分化潜能由T细胞向NK细胞转移，导致更多的造血干细胞分化为NK细胞。NK细胞在人体中的...
NK/NKT Cells and Aging 来自 Elsevier 喜欢 0 阅读量: 22 作者: CHF Liao 摘要: SUMMARY Aging involves a complex physiologic process including a decline of immune function that may contribute to morbidity and mortality due to increased susceptibility to infection, cancer, and other immune-related ...
Differential tumor surveillance by natural killer (NK) and NKT cells. I. (2000) Differential tumor surveillance by natural killer (NK) and NKT cells. J. Exp. Med. 191, 661- 668.Differential tumor surveillance by natural... - 《Journal of Experimental Medicine》 被引量: 840发表: 2000年 ...
The mesenteric lymph node (MLN) is the main draining lymph node in mouse enterocoelia, which contains many types of immune cells. Among these cells, natura
CD3-:排除T细胞,特别是NKT细胞(CD3+CD56+)。 CD56+:NK细胞的标志性表面蛋白。 CD16 +/-:部分NK细胞表达FcγRIIIA(CD16),这是识别抗体结合靶细胞的重要受体。 根据CD56和CD16的表达水平,人NK细胞可以进一步分为两个主要亚群: ①CD3-CD56dimCD16bri: ...