目前,由研究者发起的头颈癌患者iPS-NKT的I期试验正在千叶大学进行,也是iPSC来源的NKT细胞在细胞治疗中的首次临床应用。 Athenex (Kuur Therapeutics) Athenex收购细胞疗法公司Kuur Therapeutics,旗下正在开发3款CAR-NKT细胞免疫疗法,包括CMD-501、KUR-502、KU...
iNKT cells are a CD1d-restricted innate-like lineage of T cells that are prevalent in mucosal tissues, where they influence early immune responses. iNKT cells differentiate in the thymus into鈥攊NKT1, iNKT2, and iNKT17 analogous to Th1, Th2, and Th17 cells. We have shown in ET-2;CD4...
unique populations of innate-like T cells differentiate into functionally distinct effector subsets during their development in the thymus. Here, we profiled >10,000 differentiating thymic invariant natural killer T (iNKT) cells using single-cell RNA sequencing to produce a comprehensive transcriptional...
γt, to identify Tbet+NKT1, PLZFhiNKT2 and RORγt+NKT17 sublineages7,8,29,30. Interestingly, we saw that the reduction in total intrathymic iNKT cells was a result of an equivalent (~3–4-fold) reduction in all three iNKT sublineages (Fig.4b). Importantly, this reduction in iNKT c...
NKTNasal polypFlow cytometryTh2Nasal polyps (NP) are associated with inflamed mucosa of unknown etiology. The role of T cells in nasal polyposis is unclear. Invariant natural killer T cells (iNKT) can promote Th2 responses and have been implicated in some types of asthma. As there are ...
【摘要】目的 通过对比分析结核病患者与健康个体外周血中恒定自然杀伤T细胞(invariant nature killer T cells,iNKT)的比例、表型以及功能,认识iNKT细胞在结核病患者体内的功能状态,为探讨基于iNKT细胞的干预措施在结核病防治中的应用奠定基础.方法 收集武汉市新洲区人民医院收治的21例结核病患者及14例健康体检者外周血,分...
Invariant NKT (iNKT) cells are considered to be important in some autoimmune diseases including Type 1 diabetes mellitus (T1DM). So far, the published data are contradictory in regard to the role of iNKT cells in T1DM. We aimed to study iNKT cell frequency and the function of different iNKT...
c P < 0.05 vs α-Galcer. After 3 days of treatment, the expression of PLZF in DP T cells in the α-Galcer group showed no significant change (P > 0.05), and the expression of T-bet in iNKT cells was significantly decreased (P < 0.05). In the cell therapy group, the expression ...
Antibody‐dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant natural killer T cells[J]. Cancer Science, 2016, 107(3): 233-241. 13. Berzofsky J A, Terabe M. The contrasting roles of NKT cells in tumor immunity[J]. Current molecular medicine, 2009, 9(6): ...
Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets possess the most distinct location-specific fe...