Biron CA, Brossay L: NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 2001, 13:458-464.Biron, C. A., and Brossay, L. (2001). NK cells and NKT cells in innate defense against viral infections. Current Opinion in Immunology 13, 458-464. :...
1 NKT细胞的命名 于1987年在小鼠中首次发现NKT细胞之后, NKT细胞定义为既表达TCR又表达NK1.1(NKRP1c或CD161c)的一 2、类淋巴细胞, 而命名为NK1.1+T细胞(natural killer T cells)。随着研究的逐渐深入, 发现此命名并不准确, 因为在人类并不是所有表达CD161的T细胞都是NKT细胞, 也并不是NKT细胞均表达CD161。
NKT (natural killer T) cells are an innate-like lymphocyte population. They express markers associated with both T cells and NK cells. NKT cells can regulate diverse immune responses and produce large quantities of cytokines following activation. Latest Research and Reviews Direct presentation of infl...
NK and NKT cells: The innate-adaptive interface including humoral responses: NK cytokines and chemokines. In Natural Killer Cells: Basic Science and Clinical Application; Lotze, M.T., Thomson, A.W., Eds.; Elsevier/Academic Press: London, UK, 2010; p. 258....
of NKT cells is related to their unique innate capacity Although NKT cells display rearranged T cell antigen to secrete several cytokines,including IL-4and inter-receptor(TCR)chains in association with the CD3com- plex in distinction from NK cells that lack expression feron-␥(IFN␥),very ...
NK cells kill virus-infected and tumor cells by antibody dependent cell-mediated cytotoxicity (ADCC) or perforin/granzyme-mediated cytotoxicity. γδ T cells reside in mucosal and cutaneous epithelia. γδ TCRs bind to non-peptide pathogen and stress antigens that are recognized directly or when ...
2、r of NK-cells*Aggressive NK cell leukemiaSystemic EBV+ T-cell lymphoproliferative disease of childhood (associated with CAEBV)Hydroa vacciniforme-like lymphomaAdult T-cell leukemia/lymphomaExtranodal NK/T cell lymphoma, nasal typeEnteropathy-associated T-cell lymphomaHepatosplenic T-cell lymphomaSub...
The mesenteric lymph node (MLN) is the main draining lymph node in mouse enterocoelia, which contains many types of immune cells. Among these cells, natura
Natural killer (NK) and natural killer T (NKT) cells are lymphocytes that play a vital role in cell-mediated immunity. Although they belong to different lineages of cells, they share various characteristics. They are involved in cancer surveillance and represent the first line of defence against...
LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It al...