H.C. Clevers, C.L. Bevins Paneth cells: maestros of the small intestinal crypts Annu. Rev. Physiol., 75 (2013), pp. 289-311 CrossrefView in ScopusGoogle Scholar 12 Y.E. Bar-Ephraim, K. Kretzschmar, H. Clevers Organoids in immunological research Nat. Rev. Immunol., 20 (2020), ...
Correspondence to Hans Clevers. Ethics declarations Competing interests H.C. is the inventor on several patents related to organoid technology; his full disclosure is given at https://www.uu.nl/staff/JCClevers/. H.C. is the founder of OrganoidZ, which uses organoids for drug development. ...
Moreover, they were able to establish in vitro growth conditions to validate the stem cell potential of these cells: isolated Lgr5 + cells were able to generate in vitro tridimensional structures, defined as organoids, mimicking minigut with a lumen, crypt-like structures, and containing all ...
Here, we investigate the activation of six different NRs individually in human intestinal organoids using small molecules agonists. We observe changes in key enterocyte functions such as lipid, glucose, and amino acid absorption, the regulation of electrolyte balance, and drug metabolism. Our findings...
Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids Biol. Open, 4 (2015), pp. 1462-1472 CrossrefView in ScopusGoogle Scholar Gehart and Clevers, 2019 H. Gehart, H. Clevers Tales from the crypt: new insights into intestinal stem cells...
whether it can replicate there as well. They used human intestinal organoids: tiny versions of the human intestine that can be grown in the lab. Hans Clevers (Hubrecht Institute) states: "These organoids contain the cells of the human intestinal lining, making them a compelling model to inve...