Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, John Reynolds, Julene Hallo, Orla M. McNally, Thomas W. Jobling, Andrew N. Stephens, Michael A. Quinn & Magdalena Plebanski Scientific Reports ...
High levels of IL-6 in the cerebrospinal fluid derived from astrocytes after craniotomy may lead to disruption of the brain-cerebrospinal fluid barrier, most notably around the hypothalamus, which might result in inflammatory activation of microglia to damage the hypothalamic neurons and impaired ...
S4A,B). This result suggested that Bev may be more efficacious in tumors with high IL-6 expression because of the suppressive effect of IL-6 on pro-angiogenic Ang1 release. Suppression of Ang1 release by targeted siRNA restored the anti-angiogenic effects of Bev To confirm that IL-6 ...
IL-6 had very high values of PPV and NPV, NPV values being similar to other biomarkers, with significantly higher PPV values (PPV of 100% for a PR of 5, 10 and 15%; NPV of 98.7%, 97.3% and 95.8% for a PR of 5, 10 and 15%, respectively). R incón‑López et al. ...
To benefit NAFLD patients, these classifiers provide physicians and primary care doctors with a means to screen the general population for NAFLD, potentially leading to early diagnosis.In this study, we formulate a revised SEIR model incorporating latent infection transmission, asymptomatic/mild infection...
GCT usually behaves as a benign tumor, but has a significant tendency to recur locally (10%–40%) and, rarely (2%), may result in the development of lung metastases. The metastases have the same histological features as the primary tumor and are frequently curable with resection, but in ...
After siRNA was introduced, NS-SV-DC human salivary ductal cells were stimulated with IL-6 (20 ng/mL). The expression of (A) STAT3 and (B) REG Iα mRNA was measured by real-time RT-PCR using β-actin as an endogenous control. Data are expressed as means±SEM for each group (n=...
Intestinal ischemia/reperfusion (I/R) injury has high morbidity and mortality rates. Gut microbiota is a potential key factor affecting intestinal I/R injury. Populations exhibit different sensitivities to intestinal I/R injury; however, whether this int
When IL-6 production was ablated in BMSCs from IL-6 KO mice, the juxtacrine culture no longer induced IL-6 production. The experimental data from co-culture of macrophages with apoptotic BMSCs also supported this result. Once BMSCs were treated with UV light to induce their apoptosis, ...
As a result, new therapeutic approaches with lower side effects are desperately needed, and targeted therapy is a possible option [28]. In addition to being a cytoprotective cytokine in normal physiological settings, IL-6 also protects tumor cells against radiation and chemotherapy drugs, posing a...