Anakinra is an interleukin (IL)-1 receptor antagonist that exhibits properties in fighting against COVID-19.Mechanism of Action, Pharmacodynamics, and Pharmacokinetics:Anakinra is a recombinant IL-1 receptor antagonist. The epithelial cell damage that may occur with COVID-19 enhances the release of ...
N. C. The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis. Expert Opin. Investig. Drugs 17, 349–359 (2008). Article CAS PubMed Google Scholar Fitzgerald, A. A., Leclercq, S. A.,...
Interleukin 1 Receptor Antagonist Anakinra, Intravenous Immunoglobulin, and Corticosteroids in the Management of Critically Ill Adult Patients With Hemophagocytic Lymphohistiocytosis.doi:10.1177/0885066617711386Hemophagocytic lymphohistiocytosis (HLH) causes multiple organ dysfunction frequently leading to intensive care...
本发明公开了源自于IL-1受体拮抗蛋白(IL1RA)的新型肽,其能够结合至细胞表面IL1受体-1(IL1R1)并干扰IL-1与IL1R1的结合. The present invention discloses a derived IL-1 receptor antagonist (IL1RA) novel peptides capable of binding to the cell surface receptor IL1 -1 (IL1R1) and interfere with...
Interleukin-1 (IL-1) plays an important role in the pathophysiology and progression of rheumatoid arthritis (RA) by contributing to destruction of cartilage, bone, and periarticular tissues. Inhibiting IL-1 synthesis or activity with the use of recombinant human IL-1 receptor antagonist (anakinra)...
Anakinra (p.19) is a human recombinant interleukin-1 receptor antagonist used in the treatment of rheumatoid arthritis. Interleukin-2 Fusion Toxins Toxinas de fusión de interleucina 2. Profile Interleukin-2 fusion toxin is produced by replacing the receptor binding domain of diphtheria toxin with...
Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. Br. J. Dermatol. 161, 1199–1201 (2009). Article CAS PubMed Google Scholar Aksentijevich, I. et al. An ...
aThe blockade of interleukin-1 with anakinra improved glycemia and beta-cell secretory function and reduced markers of systemic inflammation. ( 正在翻译,请等待...[translate] a场景 正在翻译,请等待...[translate] aThe expression of interleukin-1–receptor antagonist is reduced in pancreatic islets of ...
Material/Methods: We studied twenty-one rats in this study They were randomly divided into three groups containing seven animals: the control group: saline-treated control; the embolism group: CTEPH normal saline; the anakinra group: CTEPH anakinra. Results: We have observe...
Interleukin 1 (IL-1) alpha and beta are potent cytokines which play key roles in inflammation. They are controlled by IL-1 receptor antagonist (IL-1ra).To ... T Andus,R Daig,D Vogl,... - Gut 被引量: 757发表: 1997年 Treatment of rheumatoid arthritis with anakinra, a recombinant hu...