Interleukin-1 receptor antagonist gene polymorphism and obesity: a pilot study from north India. Indian J Clin Biochem. 2007;22(1):61-4.P. K. Manchanda, H. K. Bid, B. R. Achyut, B. Mittal, N. Srivastava, and R. D. Mittal, "Interleukin-1 receptor antagonist gene polymorphism and ...
10]. Many pathways can regulate the inflammatory program in PDA, with interleukin (IL)-1 playing a critical role [11,12]. Intriguingly, IL-1 receptor antagonist (IL-1Ra, gene name:IL1RN)
现已克隆出IL-1受体拮抗剂(IL-1 receptor antagonist,IL-1RA),该物质可在体内外封闭IL-1的活性,是一种较理想的IL-1封闭因子。 【临床意义】 IL-1是重要的炎性介质之一,也是一种热原质成分,具有致热和介导炎症的作用。它主要在细胞免疫激活中发挥调节作用。IL-1受各种刺激因子(包括抗原、内毒素、细菌及病毒...
AIM: To investigate the relationships between polymorphisms of interleukin-1R receptor antagonist genes and susceptibility to chronic hepatitis B in Iran population.METHODS: Genomic DNA was extracted from the peripheral blood of 80 patients with chronic hepatitis B (57 males, 23 females) aged 12-77 ...
Interleukin 1 (IL-1) is a general name for two distinct proteins, IL-1 alpha and IL-1 beta, that are considered the first of a small (but possibly growing) family of regulatory and inflammatory cytokines.1 Along with IL-1 receptor antagonist (IL-1ra)2 and IL-18,3 these molecules play...
Publication » Serum levels of interleukin 1 receptor antagonist (IL1RA) and soluble tumor necrosis factor α-receptor (sTNFα-R) in severe attacks of ulcerative colitis.doi:10.1016/S0016-5085(98)84312-6PéréVergé, D.Bienvenu, J.Flourié, B....
DeBont, et al., " Increased plasma concentrations of interleukin-1 receptor antagonist in neonatal sepsis ", Pediatr. Res. 37(5):626-629, (1995).de Bont ES, de Leij LH, Okken A, Baarsma R, Kimpen JL. Increased plasma concentrations of interleukin-1 receptor antagonist in neonatal sepsis...
Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine; however, its
The invention relates to the production and expression of Interleukin 1 receptor antagonist (IL-1Ra) in expression systems, such as Pichia Pastoris ( P. pastoris ). For example, the present invention encompasses an engineered Pichia strain x-33/pGAPZαA/IL-1Ra constructed by cloning the IL-1Ra...
Additionally, it has been reported that IL-2/IL-2R interaction has a critical impact on CTLA-4 antagonist antibodies effects. IL-2 and its receptor subunits (IL-2Rα and IL-2Rβ) are critical for T cell-dependent control of tumor progression induced by CTLA-4 blockade, which could ...