Drugs exhibiting prophylactic or therapeutic applications for the treatment of diseases caused by the production of cytokines, including interleukin-1, effectively inhibiting the biological activity of cytokines. Drugs are characterized in that they are of protein products lacking a signal sequence for ...
Drugs that affect the production or action, or both, of the pleiotropic inflammatory cytokine interleukin-1 (IL-1) are predicted to have a significant impact on a variety of human diseases. The biochemical properties of IL-1 and the IL-1 receptor antagonist, the mechanism for their production...
(2012). Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: An open-label study. Allergy, 67(7), 943–950. Article CAS PubMed Google Scholar Lyseng-Williamson, K. A. (2013). Canakinumab: A guide to its use in acute gouty arthritis flares. BioDrugs, ...
10]. Many pathways can regulate the inflammatory program in PDA, with interleukin (IL)-1 playing a critical role [11,12]. Intriguingly, IL-1 receptor antagonist (IL-1Ra, gene name:IL1RN)
Interleukin (IL) -1, a proinflammatory cytokine, increases in aneurysm, and the IL-1 receptor antagonist (IL-1Ra) modulates IL-1 activity endogenously. We show here that IL-1Ra-deficiency in hematopoietic cells disrupts immune system homeostasis and causes spontaneous femoral artery aneurysms in ...
2326 Supplementary Drugs and Other Substances Interleukin-1 Receptor Antagonists Antagonista del Receptor de la Interleucina 1; IL-1ra; IL-1i; Inter- leukin-1 Inhibitors. Profile Endogenous antagonists to interleukin-1 receptor block the ac- tions of interleukin-1 (p.2325) and recombinant forms...
Pancreatic ductal adenocarcinoma (PDA) is a pernicious disease characterized by an immunosuppressive milieu that is unresponsive to current immunotherapies. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory cytokine; however, its
N. C. The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis. Expert Opin. Investig. Drugs 17, 349–359 (2008). Article CAS PubMed Google Scholar Fitzgerald, A. A., Leclercq, S. A.,...
Reply to letter by Gallo and Petrek commenting on interleukin-1 receptor antagonist and interleukin-6 polymorphisms and post-total hip arthroplasty osteolysisrheumatoid arthritiscicadian rhythmanti-inflammatory drugsglucocorticoidstimed drug releaseNo abstract is available for this article.doi:10.1002/art....
Furthermore, intrahippocampal transplantation of neural precursor cells that overexpress the IL-1 receptor antagonist, therefore blocking IL-1 signalling by chronically elevating levels of the antagonist, completely abolishes the detrimental effect of stress on neurogenesis (Ben Menachem-Zidon et al, 2008...