KINERET® (anakinra) is a prescription medicine called an interleukin-1 receptor antagonist (IL-1Ra) used to: RA:Reduce the signs and symptoms and slow the damage of moderate to severe active rheumatoid arthritis (RA) in people aged 18 years and older when 1 or more other drugs for RA ...
阿那白滞素,全称为重组人白介素-1受体拮抗剂(Recombinant Human Interleukin-1 Receptor Antagonist),它通过特异性地阻断白介素-1(IL-1)与其受体的结合,从而抑制IL-1介导的炎症反应。IL-1是一种在类风湿关节炎等多种炎症性疾病中发挥关键作用的细胞因子,它能够触发一系列炎症级联反应,导致关节损伤和功能障碍。因此...
白细胞介素-1受体缺乏症(Deficiency IL-1 Receptor Antagonist,DIRA)是由IL1RN基因的遗传突变引起的一种超罕见的自发性免疫疾病,编码白介素1受体拮抗剂(IL-1Ra)蛋白。在DIRA患者中,IL-1Ra的缺乏会导致作用异常IL-1信号转导,累及皮肤和骨骼,并导致发生威胁生命的全身性炎症。 IL1RN基因产生白介素1受体拮抗剂(...
Anakinra is an IL-1 receptor antagonist and shown to be effective for the treatment of COVID-19 in some trials but not others. Anakinra, the first in this class, seems to have a mix result for the treatment of COVID-19.doi:10.1097/MJT.0000000000001603Nguyen, Timothy...
The decision to initiate monotherapy with interleukin-1 (IL-1) receptor antagonist was based on immunohistochemical detection of the abundance of IL-1 positive cells in the patients skin biopsy. After starting treatment with anakinra, disappearance of symptoms could be observed within 24 h. ...
Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activ...
CNO可为散发,也可为单基因自身炎性疾病的表现,如IL-1受体拮抗剂缺陷(deficiency of interleukin(IL)1 receptor antagonist,DIRA)或Majeed综合征。滑膜炎、痤疮、脓疱病、骨质增生及骨炎(synovitis,acne,pustulosis,hyperostosis,and osteitis,SAPHO)是特征类似CNO综合征的成人疾病。
Anakinra (IL-1Ra);Raleukin; AMG-719;阿那白滞素,仅用于工业应用或科学研究,不可用于人类或动物的临床诊断或治疗,非药用. Raleukin (AMG-719) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonis
Kineret(anakinra)阿那白滞素是通过基因重组技术所产生的人白介素1受体拮抗剂(IL-1Ra)。阿那白滞素(anakinra)已被批准用于治疗患有系统性青少年特发性关节炎(SJIA)和成人斯蒂尔病(AOSD)。 白细胞介素-1受体缺乏症(Deficiency IL-1 Receptor Antagonist ,DIRA)是由IL1RN基因的遗传突变引起的一种超罕见的自发性免...
产品描述Anakinra is a recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the casca...