Mechanism of action Interleukin-1 (IL-1) plays an important role in inflammation and immunological responses. Inflammatory stimuli trigger its production, and it binds to the IL-1 receptor to activate a wide variety of mechanisms. The activity of the IL-1 receptor is also regulated by a natura...
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments. Treatable traits, therapeutic targets identified by phenotypes or endotypes (defined by biological mechanism or by treatment res...
It cites the inflammatory mediators that contribute to the pathogenesis of RA. It describes the significant role played by IL-1 in the inflammation and joint destruction seen in RA. Information on Anakinra's molecular structure and mechanism of action is provided. Also discussed are clinical trials...
Mechanism of Action Interleukin-1 receptor antagonist (recombinant E. coli-derived product) Blocks activity of IL-1 alpha and beta by competitively inhibiting IL-1 binding to the IL-1 type I receptor IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic re...
Mechanism Of Action KINERET blocks the biologic activity of IL-1 alpha and beta by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs. IL-1 production is induced in response to inflammatory stimuli...
A link to download a PDF version of the drug profile will be included in your email receipt. At a glance Originator AXXO Class Anti-infectives; Anti-inflammatories; Antibacterials; Antigouts; Antineoplastics; Antirheumatics; Recombinant proteins Mechanism of Action Immunomodulators; Interleukin...
Anakinra is an interleukin (IL)-1 receptor antagonist that exhibits properties in fighting against COVID-19.Mechanism of Action, Pharmacodynamics, and Pharmacokinetics:Anakinra is a recombinant IL-1 receptor antagonist. The epithelial cell damage that may occur with COVID-19 enhances the release of ...
4.1.1. Mechanism of Action Colchicine has been used for the treatment of FMF since 1973, based on an observation made by Goldfinger SE [76] and two controlled trials [6,77]. Colchicine is an alkaloid with inhibitory effects on multiple cellular functions, including microtubule assembly, cell ...