But we still recommend type I interferons serving as first-line antivirals in HCoVs infections within local protocols, and interferons may be adopted to the treatments of the SARS-CoV-2 as well. Well-designed large-scale prospective randomized control trials are greatly needed to provide more ...
Interferons induce cells to inhibit virus replication, by an intricate system that can be described as a primary line of defense activated in cells by interferon which, by itself can likely handle translation processes of some viruses. However, if viruses are able to avoid being completely ...
Interferon alfa-n3 is supplied as Alferon N 5 million international units (MIU)/1mL injection solution for intralesional injection. A dose of 0.05 mL (250,000 IU) per wart is recommended. Intralesional injections should be given twice weekly for up to 8 weeks. The maximum recommended dose ...
Additionally, MSCs can also be used as a delivery vehicle to provide sustained IFNα to the tumor microenvironment for tumor therapy. Further investigations to finetune this system will lead to better clinical strategies for MSC-based tumor therapy. Materials and methods Mice C57BL/6 and NOD-...
Enhanced Daxx expression was found to be essential in this Fas-independent apoptotic process, although its role here clearly differs from that originally described, as a consequence of its interaction with the Fas death domain (Yang et al., 1997). The present results indicate that this interferon...
S7). Nevertheless, the exact antiviral mechanism of these ISGs remains to be further investigated. Because different types of IFNs activate distinct patterns of ISGs, we hypothesized that they may function cooperatively to inhibit HuNoV replication. Indeed, we found that IFNγ exerted cooperative ...
Le-IF mRNA may be obtained from human leukocytes, ordinarily those of patients with chronic nyelogenous leukemia, that have been induced to produce interferon with Sendai or NDV virus, as described in (4). A particularly preferred source, and that used in the work reported herein, is a cell...
Interferon may be thought of as a key, with the interferon receptor as the signal lock: Crosstalk between them maintains their balance during viral infection. In this review, the protein structure of avian interferon and the interferon r... Zhou,Hao,Chen,... 被引量: 16发表: 2014年 Interfer...
These carriers may be in a crystalline or amorphous form or may be a mixture of the two. It has been found that HSA is particularly valuable as a carrier in that it provides excellent stabilization of IFN in solution. Bulking agents that are particularly valuable include compatible ...
cells are resistant to HuIFN-α1 the hybrid appears to be behaving like HuIFN-α1 in these tests. Therefore, it appears that since the hybrid has the HuIFN-α1 amino terminal sequence as its amino terminus, that portion of the protein may carry the determinant which governs cell ...