There are at least 18 interferon-α genes (including pseudogenes), one interferon-β gene, and one interferon-γ gene. Interferon-α and interferon-β have approximately 45% homology at the nucleic acid level; interferon-γ shares essentially no similarities with the other interferons. A fourth ...
eantigen and surface antigen below the level of detectability, and disappearance of the surface antigen and core antigen from liver biopsy. In the third patient there was a permanent reduction in the number of virus particles andeantigen, together with a partial reduction in the titre of surface...
IFNλ biology and signalling Four subtypes of IFNλ have been identified in humans: IFNλ1 (IL-29), IFNλ2 (IL-28A), IFNλ3 (IL-28B) and IFNλ4. SeveralIFNLpseudogenes are located in the vicinity of the genes encoding IFNλs 1–3 (ref.9), and a common dinucleotide polymorphism ...
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RESEARCHARTICLEOpenAccessVitaminDlevelsinIndiansystemiclupuserythematosuspatients:associationwithdiseaseactivityindexandinterferonalphaManamitaMand..
However, growing evidences disclosed dual role of IFN-γ signaling activation in cancer biology [9, 21, 34, 35]. While activating effective immune response, IFN-γ sensing program in malignant cells protects them from cytotoxic effect induced by IFN-γ and promotes cancer progression. IFN-γ ...
SimoneFerrero, ...NicolaRagni, inEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2004 One of the newimmunomodulatoris interferon-beta 1b (INF β-1b). It prevents relapses and progression of RR–MS. Also interferon-beta 1a (INF β-1a), a glycosylated recombinant interferon...
Kurabayashi et al., “Doxorubicin-Induced Id2A Gene Transcription Is Targeted at an Activation Transcription Factor/Cyclic AMP Response Element Mot through Novel Mechanisms Involving Protein Kinases Distinct from Protein Kinase C and Protein Kinase A” Molecular & Cellular Biology 14(11):6386-6397 (...
Using integrative genomic and computational biology approaches we will demonstrate the evolutionary conservation, information flow, connectivity, network topology and regulatory interactions underlying these ISG networks. Understanding the propagation of ISG networks in different conditions will provide a greater ...
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimm