06 Cytokine interferon/mode of actionMédecineEuropean Cytokine Network
interference: i) viral interference mediated by interferon, and ii) viral interference not mediated by interferon. The years 1958 and 1959 saw the publication of classic papers studying the mode of action and distribution of these proteins, that were found to be produced by many animals[18–21]...
Interferon:Meeting, Bonn, March 1981Properties, Mode of Action, Production, Clinical Application Edited by K. Munk; H. Kirchner S.Karger AG Volume 11 DOI: https://doi.org/10.1159/isbn.978-3-318-03394-6 Status: Available ISBN electronic: ...
: Studies on the production, mode of action and properties of interferon. Brit. J. exp. Pathol.38, 551–562 (1957). 13. Marshall, L. W., Pitha, P. M., Carter, W.: Inactivation of interferon: The effect of protonation. Virology48, 607–611 (1972). 14. Merigan, T. C., Winget...
Although they were first introduced as therapeutic agents for myeloma in 1979 their exact role in the management of myeloma remains to be precisely defined. Interferons have both anti-proliferative and immune regulation effects, but the predominant mode of action of interferons in myeloma is still ...
The therapeutic efficacy and side effects of alpha-2c-interferon (IFN-alpha 2c) treatment of hairy cell leukemia were compared between two different dose regimen: 10 patients received maximum tolerable doses of IFN-alpha 2c for 1 year (group A), and 11 patients received minimum doses of IF...
348--9. uses and administration the interferons are cytokines that have a range of activities. in addition to their action against viruses they are active against malignant neoplasms and have an immunomodu lating effect. several alfa interferons are available: interferon alfa-2a (rbe), ...
IFN-β produced in this manner turns on the first-round transcription of ISGs, including IRF7. The latter then binds to IFN-α gene promoters and turns on their expression, which then upregulate more ISG expression leading to the amplification of IFN-induced innate defenses. The ...
A cDNA corresponding to the chicken interferon-γ (IFN-γ) gene has been isolated. The invention thus provides avian IFN-γ polypeptides, nucleic acids encoding them, and their recombinant production. Th
Sonnenfeld, Time and Dosage of Immunoenhancement by Murine Type II Interferon Preparations.sup.1, 1978. Stewart and Gottlieb, Interferons and Their Actions, 1981 pp. 102-104. Werenne, Antiviral Effect of Bacterially Produced Human Interferon Against Experimental Vaccinia Infection in Calves, 1985 pp...