Interferon α/β and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J. Exp. Med. 195, 517–528 (2002). CAS PubMed PubMed Central Google Scholar Orange, J. S., Wolf, S. F. & Biron, C. A. Effects of IL-12 on the ...
Interferon-α and -β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-β-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase ...
Activation of type I IFN signalling has an important role in T helper cell differentiation and in the suppressive function of regulatory T cells. Type I IFNs both negatively and positively regulate the activation of different types of inflammasome complex and the production of interleukin-1β. In...
The mechanism of both interferon induction and anti-viral response is complicated and involves the interaction of many regulatory molecules. Interferon is now known to be a component of the large family of cytokines or interleukins.You have full access to this open access chapter, Download chapter...
Another important antagonism is between type I IFNs and interleukin-1. This antagonism was recently shown to be important inM. tuberculosisinfection and to be mediated by eicosanoids, in particular prostaglandin E2. Thus, type I IFNs are part of a complex cross-regulatory network, which le...
(TR1 cells). A subset of immunosuppressive CD4+T cells that downregulate T helper 1 (TH1) and TH2 cell responsesin vitroandin vivoby a contact-independent mechanism that is mediated by the secretion of soluble interleukin-10 and transforming growth factor-β1. ...
CD38 in SLE CD4 T cells promotes Ca2+flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane ArticleOpen access27 September 2024 T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy ...
S1C). Similarly, the number of double-positive Ly6C+CXCR3+ naïve CD8+s was also increased long term (Fig. S1D). Thus, the long-lasting increase in Ly6C expression in ‘non-SPF’ mice might be maintained by persistent/chronic infections and/or by continuous exchange of pathogens between...