The Interferons There are presently three identified categories of interferon (IFN): type 1 interferons (IFN alpha/beta, IFNα/β), the type II interferons (IFN gamma, IFNγ), and the type III interferons (the IFN lambda [IFNλ] 1–3 proteins, which are alternatively known as IL-28 and...
A disproportionate amount of body fat within the abdominal cavity, otherwise known as visceral obesity, best predicts the negative health outcomes associated with high levels body fat. Growing evidence suggests that repeated activation of the stress response can favor visceral fat deposition and that vi...
The putative keratinocyte-derived factor(s) responsible for these effects was found to be soluble and stable. By analyzing cytokines secreted by keratinocytes we identified interleukin-1α as a potent inhibitor of connective tissue growth factor mRNA expression in fibroblasts. Involvement of this ...
Conceptus-derived factors affect various aspects of endometrial function. Estrogens and IL1B2 are produced by the elongating conceptus on d 10–12 of pregnancy [2,3]. Estrogens signal a maternal recognition of pregnancy in pigs because they act on a redirection of endometrial prostaglandin (PG)...
Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring...
Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity. The recruitment of innate leukocytes has been well studied in the context of extracel
Muteins of biologically active proteins such as IFN-β and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These...
It occurs in response to an inflammatory response brought on by injury and trauma, neoplasm, or disordered immunological activity. A local reaction at the site of injury or infection leads to an activation of cytokines (specifically, IL-6, IL-1, TNF-Alpha, and interferons) that triggers a ...
Arthritis is characterized by angiogenesis and osteoclastogenesis, as well as systemic disorders including cardiovascular and pul- monary dysfunctions [1, 10]. Class II cytokines, including the interferons (α, β, γ, ε, κ, λ, ω) and IL-10 family, appear...
Although AREs are typically found in the transcripts encoding cytokines (interleukins and interferons) and oncogenes (c-...Gorospe M, Baglioni C. Degradation of unstable interleukin-1α mRNA in a rabbit reticulocyte cell-free system: Localization of an instability determinant to a cluster of A...