immune complexes, as well as the DNA and RNA-containing materials, can act as endogenous IFN inducers by activating plasmacytoid dendritic cells (pDCs) via the TLR7/TLR8 or TLR9 signaling pathway7. Secondly, genetic variants
Virus-activated pDCs also direct antigen-specific B cell differentiation into Ig-secreting plasma cells mediated by a combination of type I IFN and IL-6 signaling [114]. 2. Viral antagonism of type I IFN responses Given the effectiveness of IFN-inducible antiviral responses in limiting infection ...
B. et al. Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection. Science 297, 2063–2066 (2002). CAS PubMed Google Scholar Nguyen, K. B. et al. Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a ...
These barriers utilize nonredundant mechanisms to suppress viral infections including the production of interferons (IFNs), which induce a strong antiviral state following receptor binding. However, whereas type I IFNs control infection systemically, type III IFNs (IFN-λs) control infection locally ...
1996. Consequently, the STAT1-deficient mice are highly susceptible to viral infection and tumor progression, although they have no obvious abnormalities in lymphoid development. It was surprising, therefore, to find that STAT1 is not required for the type I interferon-induced apoptosis of B cell ...
Like RIG-I, MDA5 functioned as a sensor to detect many viral infections and was critical for type I IFN induction during viral infections (Siren et al., 2006). Notably, MDA5 recognized MNV strain MNV-1 infection in vivo and stimulated the production of type I IFNs and other cytokines (...
The proportion of double-positive Ly6C+CXCR3+ cells was also higher on d7 post-WNV infection (Fig. S1A) but this increase was lower than the ~2 fold increase in the total Ly6C+ population. To examine whether the Ly6C upregulation on CD8+ Tn cells was specific to viral infections, we ...
The type 1 interferons, and (IFN-/), are comprised act through the IFN-/receptors and STAT1 for the of the products of multiple (up to 12) IFN-genes and in... CA Biron - 《Immunity》 被引量: 1395发表: 2001年 Multicycle infection of hepatitis C virus in cell culture and inhibition...
interferons exhibiting interferon activity restricted to antiviral activity may be used to treat viral infections with a potential for interferon therapy such as encephalomyocarditis virus infection, influenza and other respiratory tract virus infections, rabies and other viral zoonoses and arbovirus ...
Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases. Inventors: Goeddel, David V. (Burlingame, CA) Pestka, Sidney (North Caldwell, NJ) Application...