Interferon-stimulated genes (ISGs) are the effectors of interferon (IFN) actions and play major roles in innate immune defense against microbial infection. During virus infection, ISGs impart antiviral actions to control virus replication and spread but can also contribute to disease pathology if ...
Interferons(IFNs) can induce the expression of IFN-stimulated genes (ISGs), such asmyxovirusresistance (Mx) protein, to inhibit virus replication. In this study, the expression of Mx gene in mandarin fish, and the IFN-sensitiveresponse elements(ISREs) and gamma-interferon activated sites (GASs...
Here, we screen a library of nearly 400 interferon-stimulated genes (ISGs) against a biologically contained Ebola virus and identify several ISGs not previously known to affect Ebola virus infection. Overexpression of the top ten ISGs attenuates virus titers by up to 1000-fold. Mechanistic studies...
Several interferon-stimulated genes (ISGs) such as IFN-stimulated protein of 15kDa (ISG15), protein kinase R (PKR), and 2鈥 5鈥 -oligoadenylate synthetase (OAS) function as antiviral effectors and might contribute to virus elimination. Nevertheless, detailed investigations of the type I IFN ...
Treatment of cells with interferons (IFNs) induces the phosphorylation of signal transducer and activator of transcription 1 (STAT1), leading to the expression of hundreds of IFN-stimulated genes (ISGs). ISGs exert various antiviral and pro-inflammatory reactions. We have previously reported that ...
“We found that 65 ISGs controlled SARS-CoV-2 infection, including some that inhibited the virus’ ability to enter cells, some that suppressed manufacture of the RNA that is the virus’s lifeblood, and a cluster of genes that inhibited assembly of the virus,” says Chanda. “What ...
Some interferon stimulated genes (ISGs) encode proteins that inhibit LINE-1 (L1) retrotransposition. Here, we use immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with the L1 ORF1-encoded protein (ORF1p) in ribonucleoprotein particles. Th...
Because the vast majority are up-regulated they are overwhelmingly referred to as IFN-stimulated genes (ISGs) so, hereafter, they will be referred to generically as ISGs (or specifically as chicken ISGs, ChISGs), except where the more generic term avoids confusion. Induc- tion of ISGs ...
Because the vast majority are up-regulated they are overwhelmingly referred to as IFN-stimulated genes (ISGs) so, hereafter, they will be referred to generically as ISGs (or specifically as chicken ISGs, ChISGs), except where the more generic term avoids confusion. Induc- tion of ISGs ...
Interferons (IFNs) are a component of an early response to invading pathogens and induce the expression of hundreds of IFN-stimulated genes (ISGs) (Schoggins et al., 2011, Stetson and Medzhitov, 2006). The IFN response can ameliorate viral disease by facilitating clearance of acute infections,...