Their repertoire has recently been expanded to the regulation of inflammasome complexes, which are cytosolic multi-protein complexes that control an inflammatory cell death called pyroptosis and the release of cytokines like interleukin-1尾 and interleukin-18. Here we discuss recent advances in ...
immunity-related GTPase; ISG15, IFN-stimulated gene 15 kDa protein; MX1, myxovirus resistance 1; NOS2, nitric oxide synthase 2; NRAMP1, natural resistance-associated macrophage protein 1; OAS, 2ʹ-5ʹ oligoadenylate synthase; PKR, IFN-induced, RNA-activated protein kinase.*Other NADPH...
Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. J. Interferon Cytokine Res. 31, 79–87 (2011). Article CAS PubMed Google Scholar Mordstein, M. et al. Interferon-λ contributes to innate immunity of mice against influenza A virus but not against ...
have no homologs in the pufferfishes, with their single tandem pair of irg proteins, and recalls the recent observation that the gap protein of the small gtpase, rap1, is itself probably derived from a gtpase ancestor, retaining the g-domain structure but not the sequence to reveal its ...
the Mx GTPase pathway, the 2′,5′-oligoadenylate-synthetase-directed ribonuclease L pathway, the protein kinase R pathway and the ISG15 ubiquitin-like pathway. As discussed in this Review, these effector pathways individually block viral transcription, degrade viral RNA, inhibit translation and modif...
Viral entry requires co-operative interactions of several host cell factors. Interferon (IFN) and the IFN-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We examined the effect of interferon-
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense. Sasai M,Sakaguchi N,Ma JS,et al. Nature Immunology . 2017Sasai, M.; Sakaguchi, N.; Ma, J.S.; Nakamura, S.; Kawabata, T.; Bando, H.; Lee, Y.; Saitoh, T.; Akira, S.; Iwasaki, A...
Gate-16 but not LC3b specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate uniform distribution of interferon-inducible GTPases. The lack of GABARAPs reduced Arf1 activation, which led to formation of interferon-inducible GTPase-containing aggregates and hampered...