ABSTRACT: Fibronectin supports TNF-a-induce osteopontin expression through b1-integrin/ERK in HNSCCExtracellular matrix (ECM) and growth factor signaling networks are known to interact in a complex manner and modulate behavior of the cells. Objectives: Herein, we investigated the influence of ...
This b1-integrin cooperation, occurs in cells grown in suspension and leads to increased anchorage-independent cell survival/ growth. We report a novel mode of integrin–RTK cooperation, which we term 'inside-in signalling'. Results c-Met and b1-integrin co-internalize in a molecular complex. ...
We identified a conserved TEAD consensus motif in the 30-untranslated region of MYL9 that was bound by a complex that included YAP-1 and was required for YAP-1 induction of a MYL9 reporter construct (Fig. 3j and Supplementary Fig. 7). Verteporfin (VP) inhibits YAP-1 function by blocking...
The structure of an activated integrin complex in its open state can be represented by the αIIBβ3 crystal structure (PDB ID 3fcu; [13]). Interestingly, up to now, only the α6 subunit has been identified to form a functional heterodimer with β4 [7,14]. Moreover, all integrins ...