“我们的研究说明,β1-integrin活性减弱的老化肌肉干细胞和纤连蛋白不足的老化肌肉,是肌肉衰老的根本原因。β1-integrin和纤连蛋白都是很有前景的治疗靶标,”卡内基科学研究所的Chen-Ming Fan表示。 骨骼肌的再生能力依赖于长寿的肌肉干细胞,也称为卫...
β1-integrin 通路(Pathway) Cytoskeleton--Integrin CAS号(CAS NO.) 1228445-38-2 分子式(Formula) C23H25N5O3S 分子量(Molecular Weight) 451.54 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure) 运输和保存方法 ...
1-integrin 来自 EBSCO 喜欢 0 阅读量: 12 摘要: The bones and connective tissues of the murine jaws and skull are partly derived from cephalic neural crest cells (CNCCs). Here, we report that mice deficient of protogenin (Prtg) protein, an immunoglobulin domain-containing receptor expressed in...
In cells growing in suspension, β1-integrin promotes sustained c-Met-dependent ERK1/2 phosphorylation on ARE. This signalling is dependent on ATG5 and Beclin1 but not on ATG13, suggesting ARE belong to a non-canonical autophagy pathway. This β1-integrin-dependent c-Met-sustained signalling ...
Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in th
β1-integrins are cell surface receptors that participate in sensing the cell's external environment. We used the Cre-lox system to delete β1-integrin in all lens cells as the lens vesicle transitions into the lens. Adult mice lacking β1-integrin in the lens are microphthalmic due to apop...
1 integrin is a prerequisite for association with the IL-3R common. Flow cytometry analysis using mAb 12G10, recognizing one epitope expressed only in the FN-competent 1 integrin (Mould et al., 1995), or mAb BV7, recognizing a constitutive 1 integrin epitope, was performed on MO7-E ...
Cross-linking of the CD28 Ag on T cells results in increased beta 1-integrin-mediated adhesion to fibronectin. Chimeric contructs containing the CD28 cytoplasmic domain fused to the extracellular and transmembrane regions of CD2 were expressed in HL60 cells to investigate CD28-mediated regulation of...
2016 | Updated 22 Jul 2016 DOI: 10.1038/ncomms11942 OPEN Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes Rachel Barrow-McGee1,*, Naoki Kishi1,*, Carine Joffre1,*,w, Ludovic Me´nard1,*,w, Alexia Hervieu1,w, Bakhouche A....
ROCK and Src to strengthen the α5β1-integrin-mediated adhesion. Furthermore, PAR signalling changes the abundance of numerous proteins in the adhesome assembled by α5β1-integrins, including Gα13, vacuolar protein-sorting-associated protein 36, and band 4.1-like protein 4B or 5, and accel...