2024年3月1日,华中科技大学同济医学院基础医学院药理学系方超教授团队在Arteriosclerosis, Thrombosis, and Vascular Biology杂志发表题为“Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment”的研究论文,揭示了细胞外 ERp72通过催化二硫键重排调控整合素Mac-1活性从而...
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activationIntegrinPesticideLearning and memory deficitsNLRP3 inflammasomeNADPH oxidaseMicroglial activation...
基因别名:CD11B; CR3A; ITGAM; MAC-1; MAC1A; MO1A; SLEB6 UniProt ID:(Human) P11215 Entrez Gene ID:(Human) 3684 功能 glycoprotein bindingprotein bindingmetal ion bindingintegrin 参与通路 cell adhesionintegrin-mediated signaling pathwayectodermal cell differentiationextracellular matrix organiz...
Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin. Through its apo(a) moiety Lp(a) specifically interacts with the beta2-integrin Mac-1, thereby promoting the adhesion of monocytes and their ... SN Sotiriou,VV Orlova,N Alfakhri,... -...
A novel pathway of HMGB1‐mediated inflammatory cell recruitment that requires Mac‐1‐integrin Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, et al. A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J 2007;26:1129-39... ...
Importantly, MACC1-overexpression was shown to increase secretion of IGFBP2, which mediates an integrin-dependent repression of PTEN activity [107,108,109]. Aside from upregulating c-MET kinase or suppressing PTEN, MACC1 seems to directly interact with YWHAE (14–3-3 epsilon), a newly ...
Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting th
RO-Heparin Inhibits β2-Integrin(Mac-1)-mediated Neutrophils AdhesionRO-Heparin Inhibits β2-Integrin(Mac-1)-mediated Neutrophils Adhesion高碘酸氧化肝素β2-整合素Mac-1嗜中性粒细胞人脐静脉内皮细胞 RO-heparinβ2-integrin Mac-1human umbilical endothelial cells HUVECsinflammationThe...
Mac-1 is an integrin expressed by macrophages that binds phosphorothionate moieties like those in OPs.Objective: We evaluated the role of macrophage Mac-1 in OP-induced increase in cytokines and growth factors and tested whether phosphorothionate OP metabolites similarly stimulate macrophages.Methods...
CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen. 应用范围:FCM 种属反应性:Mouse 免疫原:Rat 性能 形态:liquid...