LFA-1 integrin antibodies inhibit leukocyte 4 1-mediated adhesion by intracellular signaling. GRONHOLM M,JAHAN F,BRYUSHKOVA EA,et al. Blood . 2016Gronholm M, Jahan F, Bryushkova EA, Madhavan S, Aglialoro F, Soto Hinojosa L, et al. LFA-1 integrin antibodies inhibit leukocyte α4β1-...
货号 KL11049RP 淋巴细胞功能关联抗原1α(CD11a)重组蛋白 Recombinant Lymphocyte Function Associated Antigen 1 Alpha (CD11a) LFA1a; ITG-AL; LFA-1; LFA1-A; ITGAL; Integrin,Alpha L; CD11 antigen-like family member A; Leukocyte function-associated molecule 1 alpha chain来源...
当例如使用抗体非适度地靶向整合素lfa-1时,在靶向lfa-1时不可预见的效应并不少见(reina,manuel,and enric espel.“role of lfa-1and icam-1in cancer.”cancers,第9卷,11 153.2017年11月3日;m,jahan f,bryushkova ea等人,lfa-1 integrin antibodies inhibit leukocyte α4β1-mediated adhesion by intracellul...
LFA-1 protein function Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T...
1, which has intermediate affinity for ligand ICAM-1. A key finding is that KIM127-positive LFA-1 forms new adhesions at the T lymphocyte leading edge. This LFA-1 links to the cytoskeleton through alpha-actinin-1 and disruption at the level of integrin or actin results in loss of cell ...
Key words integrin; LFA-1; ICAM-1; the immune synapse; lymphocytes homing; rheumatoid arthritis; graft rejection 1 引言 胞内区与胞内的细胞骨架蛋白和信号分子结合, 通 淋巴细胞功能相关抗原-1(lymphocyte function 过由内到外(inside-out)和由外到内(outside-in)双向 associated antigen-1, LFA-1)...
该文重点介绍了LFA-1与其配体ICAM-1参与的主要生理功能以及与此相关的几种疾病。关键词 整合素; LFA-1; ICAM-1; 免疫突触; 淋巴细胞归巢; 类风湿性关节炎; 移植排斥The Biological Functions of Integrin LFA-1 and Its Ligand ICAM-1 and the Related DiseasesLi Jinli, Zhai Xinhui*(School of Life ...
LFA-1粘附分子群属于整合素(Integrin)粘附受体家族,但LFA-1抗原家族只在白细胞上表达。 【总页数】4页(P97-100) 【作者】Carl,GF;侯忠成 【作者单位】不详;不详 【正文语种】中文 【中图分类】R392.11 【相关文献】 1.华侨华人在祖籍地的作用方式研究--对融籍华侨华人创新"作用方式"的实证分析 [J], 《...
1999). In addition, the overexpression of LFA1 in tumor cells is linked to vascular invasion through adhesion to endothelial cells, suggesting a possible role in metastasis (Haake et al. 2023). Previous research has indicated that the interaction between integrin lymphocyte function-associated ...
摘要 LFA-1和ICAM-1介导的跨膜双向信号传递在淋巴细胞渗出、活化、黏附、免疫监视、免疫突触形成中都起到重要作用。L FA-1与ICAM-1转导信号依赖于两者之间结合能力的变化。L FA-1对I CAM-1结合能力的调节是一动态过程,L FA-1的亲和力和亲合力变化是两种主要调节方式。LFA-1亚单位的磷酸化、细胞骨架蛋白t a...