Instead, inhibiting integrins a1b1 and a5b1 curtails both galectin-8- and VEGF-C-mediated LEC sprouting. Together, this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways plays a key role. 1 ...
Only monocytes (CD11b is a specific marker for monocytes) are labeled (all fluorescent signals in FIG. 3B line up with fluorescent signals in FIG. 3A). Newly effluxed monocytes (FIG. 3D) are all immuno-positive for integrin a1b1 (VLA1, FIG. 3C). FIGS. 4A and 4B. Monocyte efflux is ...
8, 9 Many members of the SPRR family of proteins serve as constituents of the cornified envelope, which is an insoluble protein complex formed under the plasma membrane in the uppermost layers of stratified squamous epithelium.10, 11, 12 The cornified envelope plays a major role in the ...
Structural determinants of the selectivity of KTS-disintegrins for the a1b1 integrin. FEBS Lett 2004;577:478-482.Kisiel, D.G.; Calvete, J.J.; Katzhendler, J.; Fertala, A.; Lazarovici, P.; Marcinkiewicz, C. Structural determinants of the selectivity of KTS-disintegrins for the α1β1...
Wang CZ, Su HW, Hsu YC, Shen MR, Tang MJ (2006) A discoidin domain receptor 1/SHP-2 signaling complex inhibits {alpha}2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Mol Biol Cell 17(6):2839–2852 Article CAS PubMed PubMed...
The commercial recombinant integrins a1b1, avb3 and aIIbb3 were immobilized on ELISA plates. Various concentration of ProAgio were added into the plates. In some cases, polyLys was co-added into the plates at a final concentration of 3 mM. After incubation and extensive washing, antibody that ...
Complex patterns of expression suggest extensive roles for the α2β1 integrin in murine development. Dev. Dyn. 1994, 199, 292–314. [CrossRef] Cancers 2019, 11, 765 20 of 21 42. Pozzi, A.; Moberg, P.E.; Miles, L.A.; Wagner, S.; Soloway, P.; Gardner, H.A. Elevated matrix...
cancers Article Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer Salah Boudjadi 1, Gérald Bernatchez 2, Blanche Sénicourt 1, Marco Beauséjour 1, Pierre H. Vachon 1, Julie C. Carrier 2 and Jean-François Beaulieu 1,* ID 1 Laboratory of Intestinal Physio...