12月14日，复旦大学（附属中山医院）肝癌研究所樊嘉院士团队与上海科技大学张力烨团队及上海顿慧医疗合作，于国际顶尖肿瘤学期刊《Cancer Cell》在线发表了题为“Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma”的研究成果。研究整合分析多组学数据，在国际...
Here, we analyzed integrated multi-omics profiling including copy number variation (CNV), DNA methylation and gene expression of 8 NFPAs. Methods We collected 4 highly proliferative (hpNFPA, Ki-67 ≥ 3) and 4 lowly proliferative (Ki-67 ≤ 1) NFPAs, and comprehensively assessed CNV, DNA ...
Methylmalonic aciduria (MMA) is an inborn error of metabolism with multiple monogenic causes and a poorly understood pathogenesis, leading to the absence of effective causal treatments. Here we employ multi-layered omics profiling combined with biochemic
Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M. Guerrero, Nicholas A. Egan, Ritu Bohat, Si Chen, Caishang Zheng...
Using multi-omics consensus clustering, we distinguished two cancer subtypes (CSs) of HCC, and found that CS2 patients exhibited superior overall survival (OS) outcomes. In TCGA-LIHC, ICGC-LIRI, and multiple immunotherapy cohorts, low-CMLBS patients demonstrated favorable clinical outcomes and ...
Limited studies on multi-omics have been conducted to comprehensively investigate the molecular mechanism underlying the developmental neurotoxicity of perfluorooctanesulfonic acid (PFOS). In this study, the locomotor behavior of zebrafish larvae was assessed under the exposure to 0.1-20μM PFOS based on...
Table S1. Clinicopathologic Features, Prognosis Information, and Multi-omics Data in CCRC Cohort, Related to Figure 1 Table S2. Proteomic Subtyping and Clinicopathologic Characteristics, Related to Figure 2 Table S3. Phosphoproteomic Subtyping and Clinicopathologic Characteristics, Related to Figure 3 Table...
That better genome annotation can be achieved by the integration of high-throughput multi-omics data as achieved in our work is well supported by the recent study by Low et al. (11), in which numerous novel protein forms were discovered in the rat liver by integrating genomics, ...
from integrated multi-omics analysis. Results BPA-degrading microbial community and meta-omics analysis pipeline We enriched a BPA-degrading culture from activated sludge using BPA as the sole electron donor and carbon source. BPA concentrations were increased from 20 to ...
Patients with CKD are uniquely poised to benefit from these integrative, multi-omics approaches since the kidney biopsy, blood and urine samples used to generate these different types of molecular data are frequently obtained during routine clinical care. The ultimate goal of developing an integrated ...