12月14日，复旦大学（附属中山医院）肝癌研究所樊嘉院士团队与上海科技大学张力烨团队及上海顿慧医疗合作，于国际顶尖肿瘤学期刊《Cancer Cell》在线发表了题为“Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma”的研究成果。研究整合分析多组学数据，在国际...
Here, we analyzed integrated multi-omics profiling including copy number variation (CNV), DNA methylation and gene expression of 8 NFPAs. Methods We collected 4 highly proliferative (hpNFPA, Ki-67 ≥ 3) and 4 lowly proliferative (Ki-67 ≤ 1) NFPAs, and comprehensively assessed CNV, DNA ...
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 Chinese patients with breast cancer and systematically analyzed their genomic, transcriptomic, proteomic...
The Multi-Omics Profiling Expression Database (MOPED, http://moped.proteinspire.org ) version 2.5 is a freely accessible multi-omics expression database. Continual improvement and expansion of MOPED is driven by feedback from the Life Sciences Community. In order to meet the emergent need for ...
Comprehensive chromatin profiling in hPSCs To define the chromatin landscapes of hPSCs, we performed an integrated multi-omics analysis of naive (cultured in PXGL medium) and primed (cultured in E8 medium) H9 human embryonic stem cells (hESCs; Fig. 1a). This analysis incorporated chromatin proteom...
The multi-petal "Hutou" jasmine (Jasminum sambacvar.Trifoliatum) is highly valued for bonsai cultivation and landscape design, however, the aroma profile and mechanisms underlying floral scent formation remain elusive. In this study, we generate a nearly complete telomere-to-telomere (T2T) genome ...
and ultrastructure distortion of zebrafish brain.TCS exposure alters immune- and metabolism-related gene in the transcriptomic profileMetabolomics revales TCS disrupted the lipid and protein metabolisms and nervous system.Multi-omics analysis co-enriched lipid especially glycerophospholipid and other metabolism...
Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells Hypoxia is associated with poor prognosis in most solid tumors due to its multiple effects on therapy resistance, angiogenesis, apoptotic resistance, and t... JT Chen,CC Liu,JS Yu,... - 《Journal of Prote...
et al. An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process. Sci. Rep. 6, 37855 (2016).Mesnage, R., Agapito-Tenfen, S. Z., Vilperte, V., Renney, G., Ward, M., Seralini, G. E., et al. (...
Fig. 1: Circadian multi-omics profiling of fly heads. a WT and per0 fly heads were collected at 3 h intervals on 2 days in DD. LC-MS/MS-based proteomics and phosphoproteomics as well as RNA-seq-based transcriptomics were conducted. An integrative pipeline iCMod was implemented for analy...