12月14日，复旦大学（附属中山医院）肝癌研究所樊嘉院士团队与上海科技大学张力烨团队及上海顿慧医疗合作，于国际顶尖肿瘤学期刊《Cancer Cell》在线发表了题为“Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma”的研究成果。研究整合分析多组学数据，在国际...
Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma.doi:10.1200/JCO.2024.42.3_suppl.5561556#Background:Comprehensive molecular analyses of metastatic hepatocellular carcinoma (HCC) are lacking.Methods:Here, we generated genomic, transcriptomic, and ...
the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies
Multi-omics data for TCGA-LUAD Somatic mutation profile and segmented copy number variation (CNV) of TCGA-LUAD patients were downloaded from the TCGA database. Moreover, mRNA stemness indices and tumor mutation burden (TMB) were respectively calculated to evaluate the correlation with TRLS. In...
In summary, Aging2Cancer is a comprehensive resource for investigating the links between aging and the multiomics signatures across normal tissues and multiple cancer types. Aging2Cancer provides a user-friendly interface and serviceable modules to explore the associations between expression, genomic alter...
Nine public datasets from Gene Expression Omnibus (GEO) and ArrayExpress were mined using integrated multi-omics analysis to characterize the molecular landscape associated with neuroinflammation in NTDs. Special attention was given to the involvement of macrophages in neuroinflammation within amniotic fluid...
This signature was then examined in multi-omics data to assess its associations with patient clinical features, prognosis, cancer malignancy-related pathways, immune microenvironment, genomic characteristics, and responses to immunotherapy and targeted therapy. Finally, the genes within the signature were ...
Carbon nano sol (CNS) can markedly affect the plant growth and development. However, few systematic analyses have been conducted on the underlying regulatory mechanisms in plants, including tobacco (Nicotiana tabacum L.). Integrated analyses of phenome,
S and R indicate shoots and roots; (B) Clustering trees among the three biological replicates of each sample; (C) Principal component analysis of genome-wide differential gene expression profiling in the shoots and roots of tobacco plants under different carbon-nano sol addition concentrations. (D...
Despite the importance of a multi-omics characterization of PCSC, in-depth characterization is still deficient. In addition to our previous findings11,13 few metabolomics14 and proteomics15,16,17 studies have been published, while no lipidomic analysis has as yet been carried out on PCSCs. Furth...